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Host genome surveillance for retrotransposons by transposon-derived proteins

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  1. Article

    Open Access

    METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence

    METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent mann...

    Chen Wang, Hideki Tanizawa, Connor Hill, Aaron Havas, Qiang Zhang… in Nature Communications (2024)

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    Open Access

    Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus

    Epstein-Barr virus (EBV) genomes persist in latently infected cells as extrachromosomal episomes that attach to host chromosomes through the tethering functions of EBNA1, a viral encoded sequence-specific DNA ...

    Kyoung-Dong Kim, Hideki Tanizawa, Alessandra De Leo… in Nature Communications (2020)

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    Open Access

    Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

    Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by ...

    Osamu Iwasaki, Hideki Tanizawa, Kyoung-Dong Kim, Andrew Kossenkov… in Nature Communications (2019)

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