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  1. No Access

    Article

    Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

    Resisting and tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here genomic analyses of anatomically modern h...

    Nathan W. Zammit, Owen M. Siggs, Paul E. Gray, Keisuke Horikawa… in Nature Immunology (2019)

  2. Article

    Open Access

    IgD attenuates the IgM-induced anergy response in transitional and mature B cells

    Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. Here we define the RNA l...

    Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg… in Nature Communications (2016)

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  3. Article

    Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

    Nature 528, 370–375 (2015); doi: 10.1038/nature16165. In this Article, owing to a typesetter error the ‘received date’ was incorrectly shown as ‘5 November 2015’ instead of ‘5 November 2013’; this has been cor...

    Ingrid E. Wertz, Kim Newton, Dhaya Seshasayee, Saritha Kusam, Cynthia Lam… in Nature (2016)

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  4. No Access

    Article

    Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

    Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn’s disease. However, the role of A20 in at...

    Ingrid E. Wertz, Kim Newton, Dhaya Seshasayee, Saritha Kusam, Cynthia Lam… in Nature (2015)