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  1. Article

    Open Access

    Remimazolam-based total intravenous anesthesia in a patient with a confirmed diagnosis of malignant hyperthermia: a case report

    Malignant hyperthermia (MH) is a rare, life-threatening disorder of calcium homeostasis in skeletal muscle cells that is triggered by volatile anesthetics and succinylcholine, leading to a hypermetabolic react...

    Hiroshi Kondo, Keiko Mukaida, Kurumi Sasai, Yukiko Nao… in JA Clinical Reports (2024)

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  2. No Access

    Article

    Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report

    Malignant hyperthermia (MH) is a severe hypermetabolic disorder associated with dysregulation of calcium homeostasis and is triggered by inhalational anesthetics (isoflurane, sevoflurane, desflurane) and a dep...

    Yasuo M. Tsutsumi, Nami Kakuta, Ryosuke Kawanishi, Katsuya Tanaka… in Journal of Anesthesia (2021)

  3. Article

    Retraction Note to: Functional analysis of newly identified RYR1 variants in patients susceptible to malignant hyperthermia

    The authors have retracted this article because they did not have permission to use the data in Tables 1 and 2.

    Yuko Noda, Toshimichi Yasuda, Rieko Kanzaki, Hirotsugu Miyoshi… in Journal of Anesthesia (2020)

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  4. No Access

    Article

    RETRACTED ARTICLE: Functional analysis of newly identified RYR1 variants in patients susceptible to malignant hyperthermia

    This study aimed to evaluate whether the three ryanodine receptor type 1 (RYR1) variants (p.Ser2345Thr, p.Ser2345Arg, and p.Lys3367Arg) which we identified in Japanese malignant hyperthermia (MH) patients with a ...

    Yuko Noda, Toshimichi Yasuda, Rieko Kanzaki, Hirotsugu Miyoshi… in Journal of Anesthesia (2020)

  5. No Access

    Article

    Myotoxicity of local anesthetics is equivalent in individuals with and without predisposition to malignant hyperthermia

    Malignant hyperthermia (MH) is an inherited muscle disorder caused by abnormal elevations of intracellular calcium (Ca2+) in skeletal muscle. There are several reports of myotoxicity caused by local anesthetics, ...

    Sachiko Otsuki, Toshimichi Yasuda, Keiko Mukaida, Yuko Noda… in Journal of Anesthesia (2018)

  6. No Access

    Article

    Genetic and functional analysis of the RYR1 mutation p.Thr84Met revealed a susceptibility to malignant hyperthermia

    The aim of this study was to analyze the genetic and functional role of a novel RYR1 variant c.251 C > T (p.Thr84Met) identified in a patient with muscle weakness demonstrating MH susceptibility.

    Takashi Kondo, Toshimichi Yasuda, Keiko Mukaida, Sachiko Otsuki… in Journal of Anesthesia (2018)

  7. No Access

    Article

    Calcium channel blockers are inadequate for malignant hyperthermia crisis

    Malignant hyperthermia (MH) results from disordered calcium (Ca2+) homeostasis in skeletal muscle during general anesthesia. Although Ca2+ channel blockers may be given to treat the tachycardia and circulatory in...

    Takako Migita, Keiko Mukaida, Toshimichi Yasuda, Hiroshi Hamada… in Journal of Anesthesia (2012)

  8. No Access

    Article

    Functional analysis of ryanodine receptor type 1 p.R2508C mutation in exon 47

    Malignant hyperthermia (MH) is a pharmacogenetic disorder of intracellular calcium homeostasis with an autosomal dominant inheritance. Most of the reported mutations in exon 47 were identified in Asian patient...

    Takako Migita, Keiko Mukaida, Hiroshi Hamada, Toshimichi Yasuda… in Journal of Anesthesia (2009)

  9. No Access

    Article

    Malignant hyperthermia susceptibility diagnosed with a family-specific ryanodine receptor gene type 1 mutation

    Malignant hyperthermia (MH) is an autosomal dominant disorder of skeletal muscle calcium regulation, and the rate of calcium-induced calcium release (CICR), determined by using skinned fibers of skeletal muscl...

    Takahiro Tanabe, Makoto Fukusaki, Yoshiaki Terao… in Journal of Anesthesia (2008)

  10. No Access

    Article

    Fulminant-type malignant hyperthermia in Japan: cumulative analysis of 383 cases

    We investigated the transition of clinical signs of fulminant-type malignant hyperthermia (f-MH) by analyzing a database consisting of 383 cumulative cases of f-MH from 1961 to 2004. The cases were divided by ...

    Takako Migita, Keiko Mukaida, Masashi Kawamoto, Masako Kobayashi… in Journal of Anesthesia (2007)

  11. No Access

    Article

    Comparison of the in vitro caffeine-halothane contracture test with the Ca-induced Ca release rate test in patients suspected of having malignant hyperthermia susceptibility

    Shiro Oku, Keiko Mukaida, Shuichi Nosaka, Yoshikazu Sai… in Journal of Anesthesia (2000)

  12. No Access

    Chapter and Conference Paper

    Clinical Classification and Incidence of Malignant Hyperthermia in Japan

    Denborough and Lovell [1] first described malignant hyperthermia (MH) as an inherited syndrome in 1960. At present, it is generally accepted that MH is triggered by many anesthetics. Succinylcholine chloride (...

    Osafumi Yuge, Michio Morio, Hirosato Kikuchi, Keiko Mukaida… in Malignant Hyperthermia (1996)

  13. No Access

    Article

    Anesthetic management for liver transplantation from living donor to adult recipient

    Nobuyoshi Sato, Katsuyuki Moriwaki, Osafumi Yuge, Keiko Mukaida… in Journal of Anesthesia (1993)