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Article
Open AccessRisk factor analysis of the decrease in gait speed among Japanese older outpatients with polypharmacy
Both polypharmacy and frailty are critical issues faced by the elderly. The decrease in gait speed is an index of frailty, and it is generally associated with falls and fractures, which are risk factors requir...
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Article
Open AccessMast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency and skin disorders. Various cells including mast cells release Zn-containing granules when activated; however, the biological role ...
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Article
Open AccessAssociation between itching and the serum zinc levels in patients with varicose veins
Varicose veins commonly occur in the lower extremities and can cause pain and discomfort in the affected area. Many patients with varicose veins suffer from itching, but its cause has not been sufficiently exp...
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Article
6-(4-Amino-2-butyl-imidazoquinolyl)-norleucine: Toll-like receptor 7 and 8 agonist amino acid for self-adjuvanting peptide vaccine
Generally, small peptides by themselves are weak to induce antibody responses. Toll-like receptor (TLR) ligands are attractive candidates of vaccine adjuvants to improve their antigenicity. The covalent conjug...
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Article
Open AccessKDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR
KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of...
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Article
Open AccessZinc homeostasis and signaling in health and diseases
The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, ...
