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Article
Open AccessEnzymatization of mouse monoclonal antibodies to the corresponding catalytic antibodies
Catalytic antibodies possess a dual function that enables both antigen recognition and degradation. However, their time-consuming preparation is a significant drawback. This study developed a new method for qu...
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Article
Open AccessA new catalytic site functioning in antigen cleavage by H34 catalytic antibody light chain
The cleavage reactions of catalytic antibodies are mediated by a serine protease mechanism involving a catalytic triad composed of His, Ser, and Asp residues, which reside in the variable region. Recently, we ...
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Article
Open AccessElectrostatically-sprayed carbon electrodes for high performance organic complementary circuits
Organic thin-film transistors (OTFTs) are promising building blocks of flexible printable electronic devices. Similar to inorganic FETs, OTFTs are heterostructures consisting of metals, insulators, and semicon...
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Article
6-(4-Amino-2-butyl-imidazoquinolyl)-norleucine: Toll-like receptor 7 and 8 agonist amino acid for self-adjuvanting peptide vaccine
Generally, small peptides by themselves are weak to induce antibody responses. Toll-like receptor (TLR) ligands are attractive candidates of vaccine adjuvants to improve their antigenicity. The covalent conjug...
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Article
Muscle-Directed Anti-Aβ Single-Chain Antibody Delivery via AAV1 Reduces Cerebral Aβ Load in an Alzheimer’s Disease Mouse Model
We previously reported that anti-amyloid-beta (Aβ) single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an Alzheimer’s disea...
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Article
Open AccessCurrent status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles
Many studies are currently investigating the development of safe and effective vaccines to prevent various infectious diseases. Multiple antigen-presenting peptide vaccine systems have been developed to avoid ...
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Article
Naturally occurring catalytic antibodies: evidence for preferred development of the catalytic function in IgA class antibodies
IgG class antibodies express catalytic activities rarely and at very low levels. Here, we studied polyclonal IgA and IgG preparations from healthy human sera and saliva for the ability to hydrolyze model pepti...
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Article
Antibodies as defensive enzymes
Antibodies (Abs) and enzymes are structural and functional relatives. Abs with promiscuous peptidase activity are ubiquitous in healthy humans, evidently derived from germline variable domain immunoglobulin ge...
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Chapter
Design and synthesis of opioid mimetics containing pyrazinone ring and examination of their opioid receptor binding activity
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Chapter
Synthesis of a Covalently Reactive Antigen Analog Derived from a Conserved Sequence of HIV-1 gp120
Antibodies (Abs) and their light (L) chain subunits are reported to catalyze the cleavage of VIP, the HIV coat proteins gp41 and gpl20, Arg-vasopressin, thyroglobulin, factor VIII, prothrombin and various mode...
