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Article
Open AccessIntracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1
Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metaboli...
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Article
Open AccessFollowing replicative DNA synthesis by time-resolved X-ray crystallography
The mechanism of DNA synthesis has been inferred from static structures, but the absence of temporal information raises longstanding questions about the order of events in one of life’s most central processes....
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Article
Open AccessImpact of intracellular hemin on N-type inactivation of voltage-gated K+ channels
N-type inactivation of voltage-gated K+ channels is conferred by the N-terminal “ball” domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, ...
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Article
Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides
Fast N-type inactivation of voltage-gated K+ (Kv) channels is important in fine-tuning of cellular excitability. To serve diverse cellular needs, N-type inactivation is regulated by numerous mechanisms. Here, we ...
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Chapter and Conference Paper
Fast Computation Method of Real-Time Precise Satellite Clock Errors for Combined BDS/GPS
BeiDou Navigation Satellite System (BDS) had been officially operating since the end of 2012. It can provide service of navigation, timing, and positioning in the Asia-Pacific region. In recent years the preci...
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Chapter and Conference Paper
BDS Zero-Difference Zero-Combination Precise Point Positioning Algorithm Study
Because of the characteristics of BDS satellite constellation and the accuracy of satellite orbit and clock error, the initialization time of the traditional ionosphere-free combination precision point positio...
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Article
Open AccessDifferent gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatin in normal cells versus tumor cells
Previous work has shown that gap junction intercellular communication (GJIC) enhances cisplatin (Pt) toxicity in testicular tumor cells but decreases it in non-tumor testicular cells. In this study, these diff...
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Chapter and Conference Paper
Integrating BDS and GPS to Accelerate Convergence and Initialization Time of Precise Point Positioning
Due to the precision of BDS orbits and satellites clock, BDS PPP need long time to convergence to centimeter accuracy than GPS PPP. Combined BDS/GPS PPP can benefit from more visible satellites and enhanced sa...
