11 Result(s)

Article

Arsenic is a potent co-mutagen of ultraviolet light

Arsenic enhances the carcinogenicity of ultraviolet radiation (UVR). However, the mechanisms of arsenic-driven oncogenesis are not well understood. Here, we utilize experimental systems to investigate the carc...

Rachel M. Speer, Shuvro P. Nandi, Karen L. Cooper, **xi Zhou… in Communications Biology (2023)

Article

Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34⁺ cells and causes decreased levels of hemoglobin

Arsenic exposure poses numerous threats to human health. Our previous work in mice has shown that arsenic causes anemia by inhibiting erythropoiesis. However, the impacts of arsenic exposure on human erythropo...

Guanghua Wan, Sebastian Medina, Haikun Zhang, Rong Pan, **xi Zhou… in Scientific Reports (2021)

Article

Inhibition of red blood cell development by arsenic-induced disruption of GATA-1

Anemia is a hematological disorder that adversely affects the health of millions of people worldwide. Although many variables influence the development and exacerbation of anemia, one major contributing factor...

**xi Zhou, Sebastian Medina, Alicia M. Bolt, Haikun Zhang… in Scientific Reports (2020)

Article

Zinc causes the death of hypoxic astrocytes by inducing ROS production through mitochondria dysfunction

Cerebral ischemia triggers a cascade of events that contribute to ischemic brain damages. Zinc release and accumulation has been shown to lead to brain cell death following cerebral ischemia. However, the mech...

Rong Pan, Ke Jian Liu, Zhifeng Qi in Biophysics Reports (2019)

Article

Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke

Concern about intracerebral hemorrhage (ICH) is the primary reason for withholding tPA therapy from patients with ischemic stroke. Early blood brain barrier (BBB) damage is the major risk factor for fatal post...

Rong Pan, Kewei Yu, Theodore Weatherwax, Handong Zheng, Wenlan Liu… in Scientific Reports (2017)

Article

Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature

Stroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by...

John Weaver, Ke Jian Liu in Medical Gas Research (2015)

Article

Conference Summary and Recent Advances: the 8th Conference on Metal Toxicity and Carcinogenesis

**xi Zhou, Scott W. Burchiel, Laurie G. Hudson… in Biological Trace Element Research (2015)

Article

Extended normobaric hyperoxia therapy yields greater neuroprotection for focal transient ischemia-reperfusion in rats

Normobaric hyperoxia (NBO) therapy is neuroprotective in acute ischemic stroke. However, how long the NBO should last to obtain optimal outcome is still unclear. Reports show that ischemic penumbra blood suppl...

Zhongrui Yuan, Rong Pan, Wenlan Liu, Ke Jian Liu in Medical Gas Research (2014)

Article

Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke

Stroke is a leading cause of death and disability due to disturbance of blood supply to the brain. As brain is highly sensitive to hypoxia, insufficient oxygen supply is a critical event contributing to ischem...

Zhifeng Qi, Wenlan Liu, Yumin Luo, Xunming Ji, Ke Jian Liu in Medical Gas Research (2013)

Article

Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke

Normobaric hyperoxia (NBO) has been shown to be neuro- and vaso-protective during ischemic stroke. However, the underlying mechanisms remain to be fully elucidated. Activation of NADPH oxidase critically contr...

Wenlan Liu, Qingquan Chen, Jie Liu, Ke Jian Liu in Medical Gas Research (2011)

Article

Effect of fluoride exposure on bone metabolism indicators ALP, BALP, and BGP

To analyze the changes in serum alkaline phosphatase (ALP) and bone alkaline phosphatase (BALP) activity and changes in osteocalcin (BGP) content following fluoride exposure and, thereby, determine the referen...

Yu-e Song, Hao Tan, Ke-jian Liu… in Environmental Health and Preventive Medici… (2011)