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  1. Article

    Open Access

    Zinc causes the death of hypoxic astrocytes by inducing ROS production through mitochondria dysfunction

    Cerebral ischemia triggers a cascade of events that contribute to ischemic brain damages. Zinc release and accumulation has been shown to lead to brain cell death following cerebral ischemia. However, the mech...

    Rong Pan, Ke Jian Liu, Zhifeng Qi in Biophysics Reports (2019)

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  2. No Access

    Article

    Autophagy Mediates Astrocyte Death During Zinc-Potentiated Ischemia–Reperfusion Injury

    Pathological release of excess zinc ions and the resultant increase in intracellular zinc has been implicated in ischemic brain cell death, although the underlying mechanisms are not fully understood. Since zi...

    Rong Pan, Graham S. Timmins, Wenlan Liu, Ke Jian Liu in Biological Trace Element Research (2015)

  3. No Access

    Article

    Arsenite Interacts with Dibenzo[def,p]chrysene (DBC) at Low Levels to Suppress Bone Marrow Lymphoid Progenitors in Mice

    Arsenite (As+3) and dibenzo[def,p]chrysene (DBC), a polycyclic aromatic hyrdrocarbon (PAH), are found in nature as environmental contaminants. Both are known to individually suppress the immune system of humans a...

    Peace C. Ezeh, Fredine T. Lauer, Ke Jian Liu… in Biological Trace Element Research (2015)

  4. Article

    Conference Summary and Recent Advances: the 8th Conference on Metal Toxicity and Carcinogenesis

    **xi Zhou, Scott W. Burchiel, Laurie G. Hudson… in Biological Trace Element Research (2015)

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  5. No Access

    Article

    The Influence of Fluoride on the Expression of Inhibitors of Wnt/β-Catenin Signaling Pathway in Rat Skin Fibroblast Cells

    The effective therapy of fluoride-induced bone diseases requires an understanding of the mechanism of the disorders. Changes in the inhibitors of the Wnt/β-catenin pathway, Dickkopf-1 (Dkk-1) and Sclerostin (S...

    **ao-Li Liu, Chang-Cheng Li, Ke-Jian Liu, Cai-Yan Cui… in Biological Trace Element Research (2012)

  6. No Access

    Article

    Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes

    Arsenic is a naturally occurring element that is present in food, soil, and water. Inorganic arsenic can accumulate in human skin and is associated with increased risk of skin cancer. Oxidative stress due to a...

    Wei Ding, Laurie G. Hudson, Ke Jian Liu in Molecular and Cellular Biochemistry (2005)

  7. No Access

    Article

    Oxidative mechanism of arsenic toxicity and carcinogenesis

    Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, th...

    Honglian Shi, **anglin Shi, Ke Jian Liu in Molecular and Cellular Biochemistry (2004)

  8. No Access

    Chapter

    Spin Trap** in Vivo: Facts and Artifacts

    EPR spectroscopy is a powerful technique for the detection, identification and quantification of free radical species, and, as can be seen from other chapters in this work, has been widely used both to study b...

    Graham S. Timmins, Ke Jian Liu in In Vivo EPR (ESR) (2003)

  9. No Access

    Article

    On the application of 4-hydroxybenzoic acid as a trap** agent to study hydroxyl radical generation during cerebral ischemia and reperfusion

    Aromatic hydroxylation from the reaction between hydroxyl radical and salicylate or its related compounds has been often utilized as a marker for the generation of hydroxyl radicals. We have investigated sever...

    Miao Liu, Shimin Liu, Steven L. Peterson… in Molecular and Cellular Biochemistry (2002)

  10. No Access

    Chapter

    In vivo reduction of chromium (VI) and its related free radical generation

    Chromium (VI) compounds are widely recognized as human carcinogens. Extensive studiesin vitroand in model systems indicate that the reactive intermediate, Cr (V), generated by cellular reduction of Cr (VI), is li...

    Ke Jian Liu, **anglin Shi in Molecular Mechanisms of Metal Toxicity and Carcinogenesis (2001)

  11. No Access

    Chapter

    Effects of Ketamine/Xylazine and Pentobarbital Anesthesia on Cerebral Tissue Oxygen Tension, Blood Pressure, and Arterial Blood Gas in Rats

    General anesthesia is needed in many animal experiments in order to carry the studies out in an effective and appropriate manner. The concentration of oxygen in tissues is often a critical variable in many of ...

    Satoshi Taie, Steven B. Leichtweis, Ke Jian Liu… in Oxygen Transport to Tissue XXI (1999)

  12. No Access

    Chapter

    Thermo-Induced Phase Transitions and Regulation of Permeability of Biomimetic Membranes

    For many years membrane science was essentially subdivided into two major fields: artificial membranes used mainly in separation/purification technology and biological membranes. During the last ten years howe...

    Nikolai M. Kocherginsky, Ke Jian Liu, Harold M. Swartz in Biofunctional Membranes (1996)

  13. No Access

    Chapter

    Measurements of pO2 in Vivo, Including Human Subjects, by Electron Paramagnetic Resonance

    The purpose of this paper is to provide an illustrative description of the current state of development of the use of electron paramagnetic resonance (EPR, or completely equivalently, electron spin resonance o...

    Harold M. Swartz, Goran Bacic, Bruce Friedman… in Oxygen Transport to Tissue XVI (1994)