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In vivo reduction of chromium (VI) and its related free radical generation

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Molecular Mechanisms of Metal Toxicity and Carcinogenesis

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 34))

Abstract

Chromium (VI) compounds are widely recognized as human carcinogens. Extensive studiesin vitroand in model systems indicate that the reactive intermediate, Cr (V), generated by cellular reduction of Cr (VI), is likely the candidate for the ultimate carcinogenic form of chromium compounds. Here we review our current understanding of the in vivo reduction of Cr (VI) and its related free radical generation. Our results demonstrate that Cr (V) is indeed generated from the reduction of Cr (VI)in vivoand that Cr (V) thus formed can mediate the generation of free radicals. Cr (V) and its related free radicals are very likely to be involved in the mechanism of Cr (Vl)-induced toxicity and carcinogenesis. These studies also illustrate thatin vivoEPR spectroscopy and magnetic resonance imaging can be very useful and powerful tools for studying paramagnetic metal ions in chemical and biochemical reactions occurring in intact animals. (Mol Cell Biochem 222: 41-47, 2001)

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Author information

Authors and Affiliations

  1. College of Pharmacy, University of New Mexico, Albuquerque, NM

    Ke Jian Liu

  2. Pathology and Physiology Research Branch, National Institute For Occupational Safety and Health, Morgantown, WV, USA

    **anglin Shi

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  1. Ke Jian Liu
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  2. **anglin Shi
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Editors and Affiliations

  1. Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, 26505, Morgantown, WV, USA

    **anglin Shi , Vince Castranova  & Val Vallyathan ,  & 

  2. Occupational Safety and Health Administration, Washington DC, USA

    William G. Perry

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Liu, K.J., Shi, X. (2001). In vivo reduction of chromium (VI) and its related free radical generation. In: Shi, X., Castranova, V., Vallyathan, V., Perry, W.G. (eds) Molecular Mechanisms of Metal Toxicity and Carcinogenesis. Developments in Molecular and Cellular Biochemistry, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0793-2_6

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  • DOI: https://doi.org/10.1007/978-1-4615-0793-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5242-6

  • Online ISBN: 978-1-4615-0793-2

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