9 Result(s)
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Chapter
ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke
Excess intracellular zinc has been implicated in ischemic brain cell death. We previously reported that extracellular zinc increases intracellular free zinc level only in hypoxic astrocytes but not in normoxia...
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Article
Open AccessDoes normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature
Stroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by...
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Article
Open AccessExtended normobaric hyperoxia therapy yields greater neuroprotection for focal transient ischemia-reperfusion in rats
Normobaric hyperoxia (NBO) therapy is neuroprotective in acute ischemic stroke. However, how long the NBO should last to obtain optimal outcome is still unclear. Reports show that ischemic penumbra blood suppl...
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Article
Open AccessNormobaric hyperoxia-based neuroprotective therapies in ischemic stroke
Stroke is a leading cause of death and disability due to disturbance of blood supply to the brain. As brain is highly sensitive to hypoxia, insufficient oxygen supply is a critical event contributing to ischem...
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Article
Open AccessNormobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke
Normobaric hyperoxia (NBO) has been shown to be neuro- and vaso-protective during ischemic stroke. However, the underlying mechanisms remain to be fully elucidated. Activation of NADPH oxidase critically contr...
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Article
Effect of fluoride exposure on bone metabolism indicators ALP, BALP, and BGP
To analyze the changes in serum alkaline phosphatase (ALP) and bone alkaline phosphatase (BALP) activity and changes in osteocalcin (BGP) content following fluoride exposure and, thereby, determine the referen...
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Chapter
Spin Trap** in Vivo: Facts and Artifacts
EPR spectroscopy is a powerful technique for the detection, identification and quantification of free radical species, and, as can be seen from other chapters in this work, has been widely used both to study b...
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Chapter
Effect of Anesthesia on Cerebral Tissue Oxygen and Cardiopulmonary Parameters in Rats
General anesthesia is known to alter cardiopulmonary and hematological parameters which affect tissue oxygenation. However, the effect of various types of anesthetics on the relationship between brain tissue pO2 ...
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Chapter
Comparisons of Measurements of pO2 in Tissue In Vivo by EPR Oximetry and Micro-Electrodes
Polarographic micro-electrode measurements are very useful for measuring pO2 in vivo, especially for measurements of the variation of pO2 within a tumor (1,2,8). This method has se...
