11 Result(s)
within
Ke** Zhang
Biomedicine
Human Genetics
Pharmacology/Toxicology
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Chapter
Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein Adducts
Sensitive immunological methods are now available for the detection and quantitation of carcinogen-DNA and protein adducts. Both monoclonal and polyclonal antibodies have been developed against DNA modified by...
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Chapter
Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors
Brain tumors present a great therapeutic challenge due to their very poor prognosis (Mahaley et al, 1989). On the other hand, brain tumors have some features that make them particularly attractive for in vivo ...
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Protocol
NMR-Based Metabolomics for Biomarker Discovery
Metabolomics provides a powerful set of tools for pharmaceutical and clinical research in a number of important areas that include drug development, early disease detection, patient stratification for treatmen...
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Protocol
Pharmacogenomics: Historical Perspective and Current Status
Pharmacogenomics and its predecessor pharmacogenetics study the contribution of genetic factors to the interindividual variability in drug efficacy and safety. One of the major goals of pharmacogenomics is to ...
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Protocol
Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System
Immunoassays are one of the most commonly used biomedical techniques to detect the expression of an antibody or an antigen in a test sample. Enzyme-linked immunosorbent assay (ELISA) has been used for various ...
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Pregnancy Exposures Determine Risk of Breast Cancer in Multiple Generations of Offspring
Breast cancer is the most common non-skin cancer in women in the United States. The incidence rate of breast cancer among migrant women from Asian countries, where the breast cancer incidence is low, could ach...
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Protocol
Fast and Efficient Measurement of Clinical and Biological Samples Using Immunoassay-Based Multiplexing Systems
Immunoassay is one of the most commonly used biomedical techniques to detect the expression of an antibody or an antigen in a test sample. Enzyme-linked immunosorbent assay (ELISA) has been used for a variety ...
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Chapter
Pharmacomicrobiomics
The safety and efficacy of drugs are the key issues in clinical treatment. Classical pharmacogenomics cannot fully explain the individual differences of drug responses. Pertinent studies indicate that intestin...
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The Ethical, Legal, and Regulatory Issues Associated with Pharmacogenomics
Developed with more and more implementation of pharmacogenomics (PGx), both in clinics and extended to some testing companies, more and more issues related have arisen, as ever-increasing participants from all...
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Protocol
Analysis of Mutations in K-ras and p53 Genes in Sputum and Plasma Samples
Sputum and plasma can provide noninvasive materials to investigate biomarkers for cancer detection and diagnosis. Mutations in the K-ras oncogene and p53 suppressor gene have been frequently found in sputum an...
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Chapter
Pharmacogenomics of Anti-Infective Agents
Ever since we know that the dissimilarities of medications are influenced by the in vivo process of the body, including absorption, distribution, metabolization, and excretion, great attentions have been paid ...
