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  1. No Access

    Article

    Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499

    A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a kn...

    Haruki Azami, Yoshihiro Watanabe, Kazunari Sakai… in The Journal of Antibiotics (2024)

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    Article

    A combination strategy of a semisynthetic macrolide, 5-O-mycaminosyltylonolide with polymyxin B nonapeptide for multi-drug resistance P. aeruginosa

    The emergence and spread of antimicrobial resistant pathogens continue to threaten our ability to combat several infections. Among them, Pseudomonas aeruginosa (P. aeruginosa) poses a major threat to human health...

    Aoi Kimishima, Kazunari Sakai, Masako Honsho, Hidehito Matsui… in The Journal of Antibiotics (2023)

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    Article

    An efflux pump deletion mutant enabling the discovery of a macrolide as an overlooked anti-P. aeruginosa active compound

    Antimicrobial resistance is a serious, worldwide problem. Pseudomonas aeruginosa (P. aeruginosa) is the pathogen that poses a major threat to human health. However, resistance-nodulation-cell division type multid...

    Aoi Kimishima, Kazunari Sakai, Masako Honsho, Paul Wasuwanich… in The Journal of Antibiotics (2023)

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    Article

    Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735

    A new insecticidal meroterpenoid, named sesquicillin F (1), has been isolated from a culture broth of Mariannaea macrochlamydospora FKI-4735, together with 4-hydroxy-5,6-dimethylpyran-2-one (2). Compounds 1 and 2

    Kazunari Sakai, Masato Iwatsuki, Taichi Kaneta, Aoi Kimishima… in The Journal of Antibiotics (2021)

  5. No Access

    Article

    Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499

    An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation...

    Kazunari Sakai, Masato Iwatsuki, Masato Iizuka… in The Journal of Antibiotics (2021)

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    Article

    Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76

    Saprolegnia parasitica, belonging to oomycetes, is one of virulent pathogen of fishes such as salmon and trout, and causes tremendous damage and losses in commercial aquacultures by saprolegniasis. Previously, ma...

    Konami Takahashi, Kazunari Sakai, Wataru Fukasawa… in The Journal of Antibiotics (2018)

  7. Article

    Cladomarine, a new anti-saprolegniasis compound isolated from the deep-sea fungus, Penicillium coralligerum YK-247

    Konami Takahashi, Kazunari Sakai, Yuriko Nagano… in The Journal of Antibiotics (2017)

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