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  1. Article

    Open Access

    Bone scan index (BSI) scoring by using bone scintigraphy and circulating tumor cells (CTCs): predictive factors for enzalutamide effectiveness in patients with castration-resistant prostate cancer and bone metastases

    Reports of Bone Scan Index (BSI) calculations as imaging biomarkers to predict survival in patients with metastatic castration-resistant prostate cancer (mCRPC) have been mainly from retrospective studies. To ...

    Hisashi Hirano, Masayoshi Nagata, Naoya Nagaya, So Nakamura in Scientific Reports (2023)

  2. Article

    Open Access

    The coral reef-dwelling Peneroplis spp. shows calcification recovery to ocean acidification conditions

    Large Benthic Foraminifera are a crucial component of coral-reef ecosystems, which are currently threatened by ocean acidification. We conducted culture experiments to evaluate the impact of low pH on survival...

    Laurie M. Charrieau, Yukiko Nagai, Katsunori Kimoto, Delphine Dissard in Scientific Reports (2022)

  3. Article

    Open Access

    Decrease in volume and density of foraminiferal shells with progressing ocean acidification

    Rapid increases in anthropogenic atmospheric CO2 partial pressure have led to a decrease in the pH of seawater. Calcifying organisms generally respond negatively to ocean acidification. Foraminifera are one of th...

    Azumi Kuroyanagi, Takahiro Irie, Shunichi Kinoshita, Hodaka Kawahata in Scientific Reports (2021)

  4. Article

    Open Access

    Incretin accelerates platelet-derived growth factor-BB-induced osteoblast migration via protein kinase A: The upregulation of p38 MAP kinase

    Incretins, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), secreted from enteroendocrine cells after food ingestion, are currently recognized to regulate gluco...

    Tetsu Kawabata, Haruhiko Tokuda, Gen Kuroyanagi, Kazuhiko Fujita in Scientific Reports (2020)

  5. No Access

    Article

    Rapid glaciation and a two-step sea level plunge into the Last Glacial Maximum

    The approximately 10,000-year-long Last Glacial Maximum, before the termination of the last ice age, was the coldest period in Earth’s recent climate history1. Relative to the Holocene epoch, atmospheric carbon d...

    Yusuke Yokoyama, Tezer M. Esat, William G. Thompson, Alexander L. Thomas in Nature (2018)

  6. Article

    Open Access

    Proton pum** accompanies calcification in foraminifera

    Ongoing ocean acidification is widely reported to reduce the ability of calcifying marine organisms to produce their shells and skeletons. Whereas increased dissolution due to acidification is a largely inorga...

    Takashi Toyofuku, Miki Y. Matsuo, Lennart Jan de Nooijer in Nature Communications (2017)