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  1. No Access

    Article

    Non-genetic determinants of malignant clonal fitness at single-cell resolution

    All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles imparted by genetic intratumour heterogeneity are becoming increasingly clear1, little i...

    Katie A. Fennell, Dane Vassiliadis, Enid Y. N. Lam, Luciano G. Martelotto… in Nature (2022)

  2. Article

    Open Access

    Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

    Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable non-genetic resistance can be overcome. Using single...

    Charles C. Bell, Katie A. Fennell, Yih-Chih Chan, Florian Rambow… in Nature Communications (2019)

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    Article

    SPOP tips the balance of BETs in cancer

    Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in...

    Katie A Fennell, Mark A Dawson in Nature Medicine (2017)