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Article
Open AccessTargeting the microenvironment in the treatment of arteriovenous malformations
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain, bleeding, relentless growth, and high volume of shunted blood. Due to the high vascula...
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Article
Open AccessTachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions
Tachycardiomyopathy is characterised by reversible left ventricular dysfunction, provoked by rapid ventricular rate. While the knowledge of mitochondria advanced in most cardiomyopathies, mitochondrial functio...
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Chapter and Conference Paper
Climate Impact Chains—A Conceptual Modelling Approach for Climate Risk Assessment in the Context of Adaptation Planning
In this paper we present a conceptual framework for a climate risk assessment based on the so-called impact chains. The method follows a general assessment framework consistent with the IPCC AR5 concept on cli...
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Article
Metabolic profiles of regulatory T cells in the tumour microenvironment
Metabolic reprogramming of cancer cells generates a tumour microenvironment (TME) characterised by nutrient restriction, hypoxia, acidity and oxidative stress. While these conditions are unfavourable for infil...
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Article
Open AccessGender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes
Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bro...
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Article
Open Access1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation
The serum level of 25-hydroxyvitamin-D3 is accepted as marker for a person’s vitamin D status but its role for the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is controversially discus...
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Article
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Many tumors evolve sophisticated strategies to evade the immune system, and these represent major obstacles for efficient antitumor immune responses. Here we explored a molecular mechanism of metabolic communi...
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Article
Targeting tumor-associated acidity in cancer immunotherapy
Checkpoint inhibitors, such as cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and programmed cell death-1 (PD-1) monoclonal antibodies have changed profoundly the treatment of melanoma, renal cell carcin...
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Article
Open AccessSprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle
Sprint interval training has been reported to induce similar or greater mitochondrial adaptations to continuous training. However, there is limited knowledge about the effects of different exercise types on th...
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Article
Immunologic and metabolic characteristics of HPV-negative and HPV-positive head and neck squamous cell carcinomas are strikingly different
An HPV infection is involved in the etiology of about 25 % of head and neck squamous cell carcinomas (HNSCC). It has been postulated that a strong antitumoral immune response in HPV-positive tumors represents ...
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Chapter
Remote Sensing-Based Monitoring of Potential Climate-Induced Impacts on Habitats
Remote sensing has been established as a valuable support to field map** and monitoring of vegetation compositions, habitats, and single species. However, the time-span of data acquisition, especially of adv...
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Article
Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease
Increasing evidences suggest that mitochondrial dysfunction plays an important role in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). Alterations of mitochondrial efficiency...
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Chapter
Gruppenprozesse
Vielleicht ist Ihnen das ja auch schon einmal passiert: Sie sind auf dem Weg zu Ihrem Gleis am Berliner Hauptbahnhof. Die Feiertage stehen an und Unmengen von Menschen sind unterwegs. Ständig werden Sie angesp...
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Article
Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1β-treated human peritoneal mesothelial cells
The peritoneal mesothelium acts as a regulator of serosal responses to injury, infection, and neoplastic diseases. After inflammation of the serosal surfaces, proinflammatory cytokines induce an “activated” me...
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Article
Biphasic Oxygen Kinetics of Cellular Respiration and Linear Oxygen Dependence of Antimycin A Inhibited Oxygen Consumption
Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone-and antimycin A-inhibited ...
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Article
Mitochondrial Function in Glucocorticoid Triggered T-ALL Cells with Transgenic Bcl-2 Expression
Independent of apoptosis, dexamethasone induced and a decrease of respiration and citrate synthase activity per cell in cells with and without transgenic Bcl-2 expression. The reduction of respiration, however...
