-
Article
Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES
Per and polyfluoroalkyl substances (PFAS), including perfluorononanoic acid (PFNA) and perfluorooctanoic acid (PFOA), were detected in the community water supply of Paulsboro New Jersey in 2009.
-
Article
Open AccessGenetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure
Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the ...
-
Article
Comparison of two home sleep testing devices with different strategies for diagnosis of OSA
Home sleep testing devices are being widely used in diagnosis/screening for obstructive sleep apnea (OSA). We examined differences in OSA metrics obtained from two devices with divergent home monitoring strate...
-
Article
Open AccessParkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels
The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the ex...
-
Article
Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers
More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but reported genome-wide significant loci do not account for all the estimated heritability and provide little information...
-
Article
Comparison of particulate matter exposure estimates in young children from personal sampling equipment and a robotic sampler
Accurate characterization of particulate matter (PM) exposure in young children is difficult, because personal samplers are often too heavy, bulky or impractical to be used. The Pretoddler Inhalable Particulat...
-
Article
Open AccessChitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
Alzheimer’s disease (AD) pathology appears several years before clinical symptoms, so identifying ways to detect individuals in the preclinical stage is imperative. The cerebrospinal fluid (CSF) Tau/Aβ42 ratio is...
-
Article
Open AccessGenetic studies of plasma analytes identify novel potential biomarkers for several complex traits
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins t...
-
Article
Open AccessRole of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans
A recent study found a significant increase of ABCA7 loss-of-function variants in Alzheimer’s disease (AD) cases compared to controls. Some variants were located on noncoding regions, but it was demonstrated that...
-
Article
A post-remediation assessment in Jersey City of the association of hexavalent chromium in house dust and urinary chromium in children
Although all chromite ore processing residue (COPR) sites near residential neighborhoods in Jersey City, New Jersey have undergone remediation, recent studies found widespread, but low levels of hexavalent chr...
-
Article
Open AccessA comparison of CPAP and CPAPFLEX in the treatment of obstructive sleep apnea in World Trade Center responders: study protocol for a randomized controlled trial
Following the World Trade Center disaster, a large number of individuals involved in rescue and recovery activity were exposed to significant amounts of dust, and reported symptoms of chronic nasal and sinus i...
-
Article
Improved exposure characterization with robotic (PIPER) sampling and association with children’s respiratory symptoms, asthma and eczema
Particulate matter (PM) and its constituents are recognized risk factors for the development of respiratory symptoms and illness in children. Most measurements of exposure have relied upon stationary indoor mo...
-
Article
Acute exposure to elevated PM2.5 generated by traffic and cardiopulmonary health effects in healthy older adults
There are evidences for exposure to vehicular emissions and adverse cardiopulmonary health effects. This study attempted to further explore these effects on elderly. This study monitored personal PM2.5 concentrat...
-
Article
Children's mouthing and food-handling behavior in an agricultural community on the US/Mexico border
Children's mouthing and food-handling activities were measured during a study of nondietary ingestion of pesticides in a south Texas community. Mouthing data on 52 children, ranging in age from 7 to 53 months,...
-
Article
Contributions of children's activities to pesticide hand loadings following residential pesticide application
The role of children's activities in leading to pesticide exposure was evaluated by comparing pesticide loadings on the hands of children with the activities of the same children observed over a 4-h period. In...
-
Article
Seasonal pesticide use in a rural community on the US/Mexico border
An environmental measurement and correlation study of infant and toddler exposure to pesticides was carried out in a colonia south of the city of Laredo, Texas. As part of the study, homes were visited during the...
-
Article
Nondietary ingestion of pesticides by children in an agricultural community on the US/Mexico border: Preliminary results
An environmental measurement and correlation study of nondietary ingestion of pesticides was carried out in a colonia in south Texas. The purpose of the study was to evaluate young children's exposure to environm...
