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Article
Open AccessExercise training and bone mineral density in postmenopausal women: an updated systematic review and meta-analysis of intervention studies with emphasis on potential moderators
The aim of this systematic review and meta-analysis was (1) to determine exercise effects on bone mineral density (BMD) in postmenopausal women and (2) to address the corresponding implication of bone and meno...
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Article
Open AccessExercise and the prevention of major osteoporotic fractures in adults: a systematic review and meta-analysis with special emphasis on intensity progression and study duration
The role of exercise in preventing osteoporotic fractures is vague, and further recommendations for optimized exercise protocols are very rare. In the present work, we provided positive evidence for exercise e...
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Article
Open AccessTopographical anatomy of the albino rat’s ischiotrochanteric muscle group
The obturator internus, gemelli, and quadratus femoris muscles are thought to be postural muscles. Thus, they are in the focus of research. Although these muscles are described in other species, detailed descr...
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Article
Open AccessCirculating bioactive sclerostin levels in an Austrian population-based cohort
Circulating serum sclerostin levels are supposed to give a good estimation of the levels of this negative regulator of bone mass within bone. Most studies evaluating total serum sclerostin found different leve...
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Article
Open AccessMyostatin and markers of bone metabolism in dermatomyositis
In dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system. Several endocrine factors are involved in muscle growth and bone turnover.
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Article
Open AccessBone turnover markers in serum but not in saliva correlate with bone mineral density
Saliva was proposed as a diagnostic tool for systemic diseases. Here we determined the correlation of bone turnover markers in saliva, bone turnover markers in serum and bone mineral density in postmenopausal ...
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Article
Open AccessRomosozumab: a novel bone anabolic treatment option for osteoporosis?
Research into the drug romosozumab began with the investigation of patients with excess bone formation. The understanding of the wingless-type mouse mammary tumor virus integration site (Wnt) signaling pathway...
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Article
Open AccessAge- and Strain-Related Differences in Bone Microstructure and Body Composition During Development in Inbred Male Mouse Strains
We explored age- and strain-related differences in bone microstructure and body composition in male C57BL/6J, DBA/2JRj and C3H/J mice. Bone microstructure of the femur, tibia and L4 was assessed by μCT at the ...
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Article
Open AccessEffectiveness of anti-osteoporotic treatment after successful parathyroidectomy for primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
After successful surgery for primary hyperparathyroidism, bone mineral density (BMD) does not improve equally in all patients. As no trial has so far aimed to influence normalization of BMD, it was the goal of...
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Article
Open AccessMyostatin and other musculoskeletal markers in lung transplant recipients
Recipients of lung transplantation (LuTx) may experience impaired muscle function and bone metabolism even after rehabilitation. We investigated the potential use of musculoskeletal markers in identifying the ...
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Reference Work Entry In depth
Immunology of Osteoporosis
In healthy bone, resorption and formation are balanced. Bone metabolism involves different cells and is influenced by many regulatory factors: age, genetics, mechanical stimulus, hormones, endocrine diseases, ...
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Living Reference Work Entry In depth
Immunology of Osteoporosis
In healthy bone, resorption and formation are balanced. Bone metabolism involves different cells and is influenced by many regulatory factors: age, genetics, mechanical stimulus, hormones, endocrine diseases, ...
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Chapter
Bone Turnover Markers
Bone is a very active tissue that is constantly remodeled in order to adapt to mechanic or metabolic requirements. Since disturbances in bone remodeling may result in relevant skeletal diseases, there is great...
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Chapter
Pathophysiology of Bone Fragility
Fragility fractures are defined as fractures that occur as a result of a minimal trauma, such as a fall from standing height or less, or in the absence of an obvious trauma. When getting older, the probability...
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Chapter
Rehabilitation bei Osteoporose
Die maximale Knochenmasse wird zwischen dem 20. und 30. Lebensjahr erreicht. Danach passt sich der Knochen wechselnden Anforderungen stetig an. Dieses „remodeling“ ist unter anderem zur Reparation von Mikrotra...
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Chapter
Rehabilitation bei rheumatischen Erkrankungen
Zu den rheumatischen Erkrankungen zählen die entzündlichen Gelenkserkrankungen wie die rheumatoide Arthritis, degenerative Gelenkserkrankungen (Arthrose), Weichteilrheumatismus (Erkrankungen an Sehnen oder Sch...
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Chapter
Osteoimmunological Aspects of Biomechanics
Osteoporosis and fragility fractures are a major health concern, especially in industrialised countries. Osteoporosis per se and osteoporosis-related complications may impair functioning and health and, thus, ...
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Article
Pathophysiology of osteoporosis
Die Osteoporose ist eine klassische altersassoziierte Erkrankung, welche Frauen häufiger als Männer betrifft. Die Hypothese, daß die Osteoporose infolge einer Östrogendefizienz auftritt, wurde bereits 1941 von...
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Chapter
Physikalische Therapie und rehabilitative Maßnahmen bei rheumatischen Erkrankungen
Die rheumatischen Erkrankungen umfassen entzündliche und degenerative Gelenkserkrankungen, Knochenerkrankungen und Erkrankungen des Sehnen-Bandapparates und sonstiger Weitchteile des Bewegungsapparates. Die Ph...
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Article
Osteoporosis: Gender-specific aspects
Traditionally, osteoporosis has been regarded as a disease of postmenopausal women; nevertheless, although osteoporosis is more common in women than in men, osteoporosis in men is a frequent and a severe condi...