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  1. Article

    Open Access

    Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2

    Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium. Embryo development and endometrial receptivity must be synch...

    Aurélie Hennes, Johanna Devroe, Katrien De Clercq… in Reproductive Biology and Endocrinology (2023)

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  2. Article

    Open Access

    Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids

    Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Knowledge regarding molecular candidates involved in this early communication process is...

    Aurélie Hennes, Katharina Held, Matteo Boretto, Katrien De Clercq… in Scientific Reports (2019)

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  3. Article

    Publisher Correction: A TRP channel trio mediates acute noxious heat sensing

    In this Letter, the trace is missing in Fig. 1e. This error has been corrected online.

    Ine Vandewauw, Katrien De Clercq, Marie Mulier, Katharina Held, Silvia Pinto… in Nature (2018)

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  4. No Access

    Article

    A TRP channel trio mediates acute noxious heat sensing

    Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, wherea...

    Ine Vandewauw, Katrien De Clercq, Marie Mulier, Katharina Held, Silvia Pinto… in Nature (2018)

  5. No Access

    Chapter

    Signature and Pathophysiology of Non-canonical Pores in Voltage-Dependent Cation Channels

    Opening and closing of voltage-gated cation channels allows the regulated flow of cations such as Na+, K+, and Ca2+ across cell membranes, which steers essential physiological processes including sha** of actio...

    Katharina Held, Thomas Voets, Joris Vriens in Reviews of Physiology, Biochemistry and Ph… (2016)

  6. No Access

    Article

    Opening of an alternative ion permeation pathway in a nociceptor TRP channel

    Besides the canonical pore that allows passage of cations into the cell, the TRPM3 channel has an alternative ‘omega’ permeation pathway formed by the S1–S4 region of the protein. This peripheral pore is inwar...

    Joris Vriens, Katharina Held, Annelies Janssens… in Nature Chemical Biology (2014)