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Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth

Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. ...

Laura Schöckel, Andrea Glasauer, Farhan Basit, Katharina Bitschar… in Cancer & Metabolism (2015)