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Reply to ‘Questioning antiviral RNAi in mammals’
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Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells
Influenza A virus (IAV) causes annual epidemics and occasional pandemics, and is one of the best-characterized human RNA viral pathogens1. However, a physiologically relevant role for the RNA interference (RNAi) ...
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A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming
The mechanisms by which pathogens evade elimination without affecting host fitness are not well understood. For the pathogen Pseudomonas aeruginosa, this evasion appears to be triggered by excretion of the quorum...