23 Result(s)

Article

Contribution of changes in the orexin system and energy sensors in the brain in depressive disorder - a study in an animal model

Maternal elevated glucocorticoid levels during pregnancy can affect the develo** fetus, permanently altering the structure and function of its brain throughout life. Excessive action of these hormones is kno...

Katarzyna Głombik, Magdalena Kukla-Bartoszek, Katarzyna Curzytek… in Pharmacological Reports (2024)

Article

Introduction to the Special Section on “Energy metabolism in the physiology and pathology of the central nervous system”

Katarzyna Głombik, Katarzyna Kuter-Nowak in Pharmacological Reports (2022)

Article

Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism

Metabolic disturbances in the brain are assumed to be early changes involved in the pathogenesis of depression, and these alterations may be intensified by a deficiency of thyroid hormones. In contrast to gluc...

Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek… in Pharmacological Reports (2022)

Article

Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression

Depression is a highly prevalent mood disorder and one of the major health concerns in modern society. Moreover, it is characterized by a high prevalence of coexistence with many other diseases including metab...

Jan Detka, Katarzyna Głombik in Pharmacological Reports (2021)

Article

Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes

Current data suggest an important role of brain metabolic disturbances in the pathogenesis of depression and obesity, diseases that frequently co-occur. Our aim was to determine whether there are changes in ma...

Katarzyna Głombik, Jan Detka, Joanna Góralska, Anna Kurek… in Neurotoxicity Research (2020)

Article

Inflammatory Consequences of Maternal Diabetes on the Offspring Brain: a Hippocampal Organotypic Culture Study

Gestational diabetes is a disorder associated with abnormal chronic inflammation that poses a risk to the develo** fetus. We investigated the effects of experimentally induced diabetes (streptozotocin model)...

Katarzyna Głombik, Ewa Trojan, Anna Kurek, Bogusława Budziszewska… in Neurotoxicity Research (2019)

Article

The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression

A growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drug...

Katarzyna Głombik, Aneta Stachowicz, Rafał Olszanecki… in Molecular Neurobiology (2016)

Article

Pro-apoptotic Action of Corticosterone in Hippocampal Organotypic Cultures

Elevated levels of glucocorticoids exert neurotoxic effects, and the hippocampus is particularly sensitive to the effects of glucocorticoids. Because some data have indicated that an increased action of glucoc...

Anna Kurek, Mateusz Kucharczyk, Jan Detka, Joanna Ślusarczyk… in Neurotoxicity Research (2016)

Article

The Beneficial Impact of Antidepressant Drugs on Prenatal Stress-Evoked Malfunction of the Insulin-Like Growth Factor-1 (IGF-1) Protein Family in the Olfactory Bulbs of Adult Rats

Insulin-like growth factor-1 (IGF-1) promotes the growth, differentiation, and survival of both neurons and glial cells, and it is believed to exert antidepressant-like activity. Thus, disturbances in the IGF-...

Ewa Trojan, Katarzyna Głombik, Joanna Ślusarczyk… in Neurotoxicity Research (2016)

Article

Influence of acute peripheral administration of lipopolysaccharide on the level of IGFBP4 in an animal model of depression

Ewa Szczęsny, Agnieszka Basta-Kaim, Katarzyna Głombik… in Pharmacological Reports (2012)

Article

The effect of prenatal stress on the expression of insulin receptor substrate family: an implication for depression

Katarzyna Głombik, Agnieszka Basta-Kaim, Agnieszka Zelek-Molik… in Pharmacological Reports (2012)

Article

Concentrations of glucose metabolites in the brain in an animal model of depression

Katarzyna Głombik, Bogusława Budziszewska, Agnieszka Basta-Kaim… in Pharmacological Reports (2011)