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Article
Open AccessMultiple bronchial carcinoids associated with Cowden syndrome
Cowden syndrome (CS) is a rare genetic condition due to the various germline mutations in the phosphatase and tensin homologue on chromosome ten (PTEN) tumour suppressor gene. As a result, CS is characterised by ...
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Article
Open AccessMiR-200b categorizes patients into pancreas cystic lesion subgroups with different malignant potential
Extracellular vesicles (EV) carry their cargo in a membrane protected form, however, their value in early diagnostics is not well known. Although pancreatic cysts are heterogeneous, they can be clustered into ...
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Article
Open AccessEarly prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases
Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or l...
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Article
Open AccessAutophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis
Although the role of autophagy has been implicated in several forms of chronic hepatitis, it is still not fully understood. Active autophagy eliminates damaged molecules and organelles (such as mitochondria) b...
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Article
Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis
Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from the biliary system with increasing incidence and mortality worldwide. Several new classifications review the significance ...
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Article
Open AccessTrue MEN1 or phenocopy? Evidence for geno-phenotypic correlations in MEN1 syndrome
Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the genotype has been observed. Mutation-negativ...
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Article
MEN1 mutations and potentially MEN1-targeting miRNAs are responsible for menin deficiency in sporadic and MEN1 syndrome-associated primary hyperparathyroidism
Inherited, germline mutations of menin-coding MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), while somatic MEN1 mutations are the sole main driver mutations in sporadic primary hyperparathyroidism (P...
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Article
FDG-PET-CT in the early response evaluation for primary systemic therapy of breast cancer
Primary systemic therapy (PST) is a standard treatment for patients with locally advanced breast cancer. We report one of our patients to demonstrate the optimal use of FDG-PET-CT in the routine clinical worku...
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Article
Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: a report of two cases
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin’s lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The dise...
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Article
Cushing’s Syndrome in a Child with Pancreatic Acinar Cell Carcinoma
A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing’s syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentration...
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Article
Claudin expression in pancreatic endocrine tumors as compared with ductal adenocarcinomas
Altered expression of recently described claudins (CLDNs) as members of tight junction (TJ) transmembrane proteins was noted in several malignancies. We aimed to analyze protein and messenger RNA (mRNA) expres...
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Article
Prenatal diagnosis of a giant congenital primary cerebral hemangiopericytoma
Congenital primary intracraniai hemangiopericytomas are exceptionally rare tumors. We present a case of a fetus, with the prenatal sonogram at 33 weeks of gestation revealing a large cerebral tumor. Because of...