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Article
Open AccessAlterations of nocturnal activity in rats following subchronic oral administration of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline
1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) is neurotoxic when administered to the brain and alters motor behaviour following intraperitoneal administration. We have assessed the long-term effects...
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Article
The analysis system COGITAT for the study of cognitive deficiencies in rodents
COGITAT is an automated hole board system that, following minimal experimental interventions, makes it possible to measure a variety of parameters associated with learning, memory, relearning, cognition, and c...
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Chapter
Highly Halogenated Tetrahydro-β-Carbolines as a New Class of Dopaminergic Neurotoxins
The Pictet-Spengler condensation of 2-arylethylamines with aldehydes or α-keto acids (Callaway et al., 1994) is not only the most efficient pathway for the chemical synthesis of tetrahydro-β-carbolines (TH-βCs...
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Chapter
Neuronal Necrosis After Forebrain Ischemia Affects Gabaergic Neurons in the Substantia Nigra and Striatum
Transient forebrain ischemia is known to produce selective neuronal cell death in the CAI sector of the hippocampus in rats (Pulsinelli et al., 1982; Schmidt-Kastner and Freund, 1991). As the cell death within...
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Article
Anticonvulsant action of 1,3-dimethyl-5-aminoadamantane
The anticonvulsant actions of memantine (1,3-dimethyl-5-aminoadamantane) have been evaluated in mice (seizures induced by maximal electroshock, pentylenetetrazol, bicuculline, picrotoxin, 3-mercaptopropionic a...
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Article
Interaction between phenytoin and diazepam in mutant Han-Wistar rats with progressive spastic paresis
The muscle relaxant (antispastic) effect of diazepam, alone or in combination with phenytoin, was studied in mutant Han-Wistar rats with progressive spastic paresis. Alone, phenytoin did not alter the spontane...
