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  1. Article

    Open Access

    Early Synaptic Alterations and Selective Adhesion Signaling in Hippocampal Dendritic Zones Following Organophosphate Exposure

    Organophosphates account for many of the world’s deadliest poisons. They inhibit acetylcholinesterase causing cholinergic crises that lead to seizures and death, while survivors commonly experience long-term n...

    Karen L. G. Farizatto, Michael F. Almeida, Ronald T. Long in Scientific Reports (2019)

  2. No Access

    Article

    Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon

    The anticholinesterase paraoxon (Pxn) is related to military nerve agents that increase acetylcholine levels, trigger seizures, and cause excitotoxic damage in the brain. In rat hippocampal slice cultures, hig...

    Karen L. G. Farizatto, Sara A. McEwan, Vinogran Naidoo in Journal of Molecular Neuroscience (2017)

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    Article

    Rotenone-Dependent Changes of Anterograde Motor Protein Expression and Mitochondrial Mobility in Brain Areas Related to Neurodegenerative Diseases

    The presence of protein aggregates is common in neurodegenerative disorders; however, the real cause and effect of these aggregates during neurodegeneration is still a matter of investigation. We hypothesize t...

    Thaiany Q. Melo, Aline M. D’unhao in Cellular and Molecular Neurobiology (2013)