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Article
Open AccessNovel design of inspiratory flow generation and gas mixing for critical care ventilators suitable for rapid production and mass casualty incidents
Scarcity of medical resources inspired many teams worldwide to design ventilators utilizing different approaches during the recent COVID-19 pandemic. Although it can be relatively easy to design a simple venti...
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Article
Open AccessFrequency and duration of extreme hypoxemic and hyperoxemic episodes during manual and automatic oxygen control in preterm infants: a retrospective cohort analysis from randomized studies
Neonatal exposure to episodic hypoxemia and hyperoxemia is highly relevant to outcomes. Our goal was to investigate the differences in the frequency and duration of extreme low and high SpO2 episodes between auto...
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Article
Open AccessTidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation
The role of high-frequency oscillatory ventilation (HFOV) has long been debated. Numerous studies documented its benefits, whereas several more recent studies did not prove superiority of HFOV over protective ...
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Article
Open AccessPerlite is a suitable model material for experiments investigating breathing in high density snow
Outdoor breathing trials with simulated avalanche snow are fundamental for the research of the gas exchange under avalanche snow, which supports the development of the international resuscitation guidelines. H...
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Article
Open AccessPhrenic nerve stimulation prevents diaphragm atrophy in patients with respiratory failure on mechanical ventilation
Diaphragm atrophy and dysfunction is a major problem among critically ill patients on mechanical ventilation. Ventilator-induced diaphragmatic dysfunction is thought to play a major role, resulting in a failur...
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Article
Open AccessIntravenous administration of normal saline may be misinterpreted as a change of end-expiratory lung volume when using electrical impedance tomography
Electrical impedance tomography (EIT) is a noninvasive imaging modality that allows real-time monitoring of regional lung ventilation. The aim of the study is to investigate whether fast saline infusion causes...
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Chapter and Conference Paper
Breathing Experiments into the Simulated Avalanche Snow: Medical and Technical Issues of the Outdoor Breathing Trials
Avalanche burials represent one of the most dangerous risks associated with winter activities in the mountains. Asphyxiation occurs as a consequence of blocked airways; or, due to a severe hypoxia and hypercap...
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Chapter and Conference Paper
Design and Demonstration of a Complex Neonatal Physiological Model for Testing of Novel Closed-Loop Inspired Oxygen Fraction Controllers
Recently published clinical trials document that manual control of oxygen fraction in the inspiratory gas in neonates is not prompt enough to react to the rapidly changing physiological status of a neonate. As...
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Chapter and Conference Paper
Center of Ventilation—Methods of Calculation Using Electrical Impedance Tomography and the Influence of Image Segmentation
Electrical impedance tomography (EIT) is a promising non-invasive, radiation-free imaging modality. Using EIT-derived index Center of ventilation (CoV), ventral-to-dorsal shifts in distribution of lung ventila...
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Article
Open AccessDelivery of heliox with a semi-closed circuit during spontaneous breathing: a comparative economic theoretical study
Heliox is a mixture of oxygen and helium which reduces airway resistance in patients with airway obstruction. In clinical practice, patients breathing spontaneously receive heliox via an open circuit. Recently...
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Chapter and Conference Paper
Design and Evaluation of a System Assuring Spontaneous Breathing in Patients Connected to a High-Frequency Oscillatory Ventilator
Patients connected to a high-frequency oscillatory ventilator should be paralysed or highly sedated so that the ventilator is able to work. The aim of the study is to design a special “Demand Flow System” allo...
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Article
Open AccessUnloading work of breathing during high-frequency oscillatory ventilation: a bench study
With the 3100B high-frequency oscillatory ventilator (SensorMedics, Yorba Linda, CA, USA), patients' spontaneous breathing efforts result in a high level of imposed work of breathing (WOB). Therefore, spontane...
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Article
Open AccessImposed work of breathing during high-frequency oscillatory ventilation: a bench study
The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a benc...
