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  1. Article

    Open Access

    Proteomic networks associated with tumor-educated macrophage polarization and cytotoxicity potentiated by heat-killed tuberculosis

    Local administration of attenuated mycobacterium has been used as a cancer treatment adjuvant to re-boost patient immune responses with variable clinical outcomes. We aimed to clarify the impact of attenuated ...

    Denise U. Putri, Po-Hao Feng, Chiou-Feng Lin, Sofia M. Haryana in Scientific Reports (2022)

  2. Article

    Open Access

    The effects of fine and coarse particulate matter on lung function among the elderly

    Impaired lung function is associated with morbidity and mortality in the elderly. However, there is a paucity of data regarding the long-term effects of particulate matter (PM) on lung function among the elder...

    Chi-Hsien Chen, Chih-Da Wu, Hung-Che Chiang, Dachen Chu, Kang-Yun Lee in Scientific Reports (2019)

  3. Article

    Open Access

    Effects of PM2.5 on Skeletal Muscle Mass and Body Fat Mass of the Elderly in Taipei, Taiwan

    Loss of skeletal muscle mass is common with aging and can cause morbidity and mortality in the elderly. The effects of particulate air pollution on skeletal muscle mass is not known. The study aims to assess t...

    Chi-Hsien Chen, Li-Ying Huang, Kang-Yun Lee, Chih-Da Wu in Scientific Reports (2019)

  4. Article

    Open Access

    Relationships of Haptoglobin Phenotypes with Systemic Inflammation and the Severity of Chronic Obstructive Pulmonary Disease

    Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and ...

    Pao-Lin Lee, Kang-Yun Lee, Tsai-Mu Cheng, Hsiao-Chi Chuang in Scientific Reports (2019)

  5. Article

    Open Access

    Correction: Corrigendum: SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD

    Scientific Reports 7: Article number: 46667; published online: 20 April 2017; updated: 22 December 2017. The original version of this Article contained errors in the numbering of affiliations where Affiliation...

    Tzu-Tao Chen, Sheng-Ming Wu, Shu-Chuan Ho, Hsiao-Chi Chuang in Scientific Reports (2017)

  6. Article

    Open Access

    SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD

    Chronic obstructive pulmonary disease(COPD) is characterized by enhanced chronic inflammation in the airways, lung parenchyma, and circulation. We investigated whether SUV39H1, a histone methyltransferase, is ...

    Tzu-Tao Chen, Sheng-Ming Wu, Shu-Chuan Ho, Hsiao-Chi Chuang in Scientific Reports (2017)

  7. Article

    Open Access

    Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle

    Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective...

    Shu-Chuan Ho, Sheng-Ming Wu, Po-Hao Feng, Wen-Te Liu, Kuan-Yuan Chen in Scientific Reports (2017)