7 Result(s)
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Kanakaraju Kaliannan
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Article
Open AccessEffects of exenatide on urinary albumin in overweight/obese patients with T2DM: a randomized clinical trial
In this study, we investigated the effect of exenatide (EXE), a glucagon-like peptide (GLP)-1 receptor agonist, on kidney function, obesity indices, and glucose control in overweight/obese patients with type 2...
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Article
Open AccessMulti-omic analysis in transgenic mice implicates omega-6/omega-3 fatty acid imbalance as a risk factor for chronic disease
An unbalanced increase in dietary omega-6 (n-6) polyunsaturated fatty acids (PUFA) and decrease in omega-3 (n-3) PUFA in the Western diet coincides with the global rise in chronic diseases. Whether n-6 and n-3...
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Article
Open AccessEstrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice
Understanding the mechanism of the sexual dimorphism in susceptibility to obesity and metabolic syndrome (MS) is important for the development of effective interventions for MS.
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Article
Compromise of α-Defensin Function in Liver Cirrhosis Facilitates the Toxic Relationship Between Gut Permeability and Endotoxemia
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Article
Open AccessMaternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota
The early-life gut microbiota plays a critical role in host metabolism in later life. However, little is known about how the fatty acid profile of the maternal diet during gestation and lactation influences th...
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Article
Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice
Bacterially derived factors from the gut play a major role in the activation of inflammatory pathways in the liver and in the pathogenesis of alcoholic liver disease. The intestinal brush-border enzyme intesti...
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Open AccessA host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia
Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic low grade inflammation that underlies many chronic diseases. Here we show that mice fed a diet high in omega-6 fatty ac...
