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Article
Open AccessAmino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice
H7N9 subtype avian influenza viruses (AIVs) cause 1567 human infections and have high mortality, posing a significant threat to public health. Previously, we reported that two avian-derived H7N9 isolates (A/ch...
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Article
Martingale inequalities in Orlicz–Karamata modular spaces
In this article, some new martingale inequalities in the framework of Orlicz–Karamata modular spaces are discussed. More precisely, we establish modular inequalities associated with Orlicz functions and slowly...
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Article
Open AccessThe haemagglutinin–neuraminidase protein of velogenic Newcastle disease virus enhances viral infection through NF-κB-mediated programmed cell death
The haemagglutinin–neuraminidase (HN) protein, a vital membrane glycoprotein, plays a pivotal role in the pathogenesis of Newcastle disease virus (NDV). Previously, we demonstrated that a mutation in the HN pr...
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Article
Structural insights into vesicular monoamine storage and drug interactions
Biogenic monoamines—vital transmitters orchestrating neurological, endocrinal and immunological functions1–5—are stored in secretory vesicles by vesicular monoamine transporters (VMATs) for controlled quantal rel...
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Article
Martingale Hardy–Orlicz-amalgam spaces
In this article, the authors first introduce a class of Orlicz-amalgam spaces, which defined on a probabilistic setting. Based on these Orlicz-amalgam spaces, the authors introduce a new kind of Hardy type spa...
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Article
Open AccessDiverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases
Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood. In particular, the role of the intri...
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Article
Microgravity Anomaly Extraction Technique Based on the MSSF and Its Application to the Identification of Reservoir Fluid Dynamic Changess
In order to improve the accuracy of gravity anomaly data processing, this study utilizes multi-scale surface fitting techniques (MSSF) to separate the Bouguer gravity field into residual gravity fields and reg...
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Article
Music genre classification based on res-gated CNN and attention mechanism
The amount of digital music available on the internet has grown significantly with the rapid development of digital multimedia technology. Managing these massive music resources is a thorny problem that powerf...
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Chapter and Conference Paper
Research on the THMC Coupling Model for Enhanced Geothermal Systems Based on the Framework of EDFM
The Enhanced Geothermal System (EGS) involves a complex thermo-hydro-mechanical-chemical (THMC) coupling process during long-term heat extraction. However, many models used to solve fractured reservoir problem...
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Article
Epithelial CRL4DCAF2 Is Critical for Maintaining Intestinal Homeostasis Against DSS-Induced Colitis by Regulating the Proliferation and Repair of Intestinal Epithelial Cells
Inflammatory bowel disease (IBD) is currently gaining an increasing global interest. Intestinal epithelial barrier dysfunction is crucial toward develo** IBD; however, the underlying mechanisms are not yet e...
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Article
Open AccessCellular vimentin regulates the infectivity of Newcastle disease virus through targeting of the HN protein
The haemagglutinin-neuraminidase (HN) protein plays a crucial role in the infectivity and virulence of Newcastle disease virus (NDV). In a previous study, the mutant HN protein was identified as a crucial viru...
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Article
Strip segmentation of oceanic internal waves in SAR images based on TransUNet
The development of oceanic remote sensing artificial intelligence has made possible to obtain valuable information from amounts of massive data. Oceanic internal waves play a crucial role in oceanic activity. ...
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Article
Real Interpolation Between Strong Martingale Hardy Spaces
In this paper, we establish a decomposition theorem for strong martingale Hardy space \(sH_p^\sigma \) ...
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Article
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress
Diabetic wounds are a serious complication of diabetes mellitus (DM) that can lead to persistent infection, amputation, and even death. Prolonged oxidative stress has been widely recognized as a major instigat...
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Article
Open AccessExosomal miR-125b-5p derived from adipose-derived mesenchymal stem cells enhance diabetic hindlimb ischemia repair via targeting alkaline ceramidase 2
Ischemic diseases caused by diabetes continue to pose a major health challenge and effective treatments are in high demand. Mesenchymal stem cells (MSCs) derived exosomes have aroused broad attention as a cell...
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Article
Liposomal Doxorubicin: the Sphingomyelin/Cholesterol System Significantly Enhances the Antitumor Efficacy of Doxorubicin
Doxorubicin (DOX) has a cytotoxic effect on many tumor cells; however, its clinical application is limited owing to its strong side effects. Although Doxil® reduces the cardiotoxicity of free DOX, it has also ...
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Article
Increased soluble sugar accumulation in postharvest peaches in response to different defense priming elicitors
A so-called priming defense is activated only when a plant suffers from heavy pathogenic invasion, thus avoiding excessive energy and material costs under low pathogen loads. In our previous studies, we demons...
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Article
Open AccessCannabinoid non-cannabidiol site modulation of TRPV2 structure and function
TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 a...
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Article
Open AccessConditional QTL map** for seed germination and seedling traits under salt stress and candidate gene prediction in wheat
Breeding new wheat varieties with salt resistance is one of the best ways to solve a constraint on the sustainability and expansion of wheat cultivation. Therefore, understanding the molecular components or ge...
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Article
An Application of Tumor-Associated Macrophages as Immunotherapy Targets: Sialic Acid–Modified EPI-Loaded Liposomes Inhibit Breast Cancer Metastasis
Breast cancer metastasis is an important cause of death in patients with breast cancer and is closely related to circulating tumor cells (CTCs) and the metastatic microenvironment. As the most infiltrating imm...
