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  1. Article

    Open Access

    Emergence of T cell immunosenescence in diabetic chronic kidney disease

    Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced...

    Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu in Immunity & Ageing (2020)

  2. Article

    Open Access

    Plasma Leucine-Rich α-2-Glycoprotein 1 Predicts Cardiovascular Disease Risk in End-Stage Renal Disease

    Plasma leucine-Rich α-2-glycoprotein 1 (LRG1) is an innovative biomarker for inflammation and angiogenesis. Many adverse pathophysiological changes including inflammation, atherosclerosis, and premature mortal...

    Feng-Jung Yang, Chun-Yih Hsieh, Kai-Hsiang Shu, I-Yu Chen, Szu-Yu Pan in Scientific Reports (2020)

  3. Article

    Open Access

    A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study

    Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown.

    Yen-Ling Chiu, Kai-Hsiang Shu, Feng-Jung Yang, Tzu-Ying Chou in Immunity & Ageing (2018)

  4. Article

    Open Access

    Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease

    Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individual...

    Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen in Immunity & Ageing (2018)

  5. Article

    Open Access

    Urinary π-glutathione S-transferase Predicts Advanced Acute Kidney Injury Following Cardiovascular Surgery

    Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomar...

    Kai-Hsiang Shu, Chih-Hsien Wang, Che-Hsiung Wu, Tao-Min Huang in Scientific Reports (2016)