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Article
MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation
Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway. These proteins, which coactivate LArge Tumour Suppressor homologue kinases, are also tumour suppressors. To investigate MOB1...
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Chapter and Conference Paper
Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for Prevention of type 2 Diabetes
*The analysis using the DBNBS reduction method and the DCFH-DA intracellular reactive oxygen species (ROS) determination method revealed that ERW and diseases-improvable natural waters such as Nordenau water i...
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Article
Demonstration of reversed flow in segmental branches of the portal vein with hand-held color Doppler ultrasonography after hematopoietic stem cell transplantation
Hepatic veno-occlusive disease (VOD) is a severe complication of hematopoietic stem cell transplantation (SCT). When monitored with hand-held color Doppler ultrasonography during day −7 to +35 around SCT, reve...
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Chapter and Conference Paper
Suppression of Cell Growth by Platinum Nanocolloids as Scavengers against Reactive Oxygen Species
Electrolysed-reduced water (ERW) contained Platinum nanocolloids (PtNCs) of 1–10 nm, suggesting that PtNCs in ERW functioned as active hydrogen donors and scavenge intracellular reactive oxygen species (ROS). ...
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Chapter and Conference Paper
Effect of Reduced Water on the Apoptotic Cell Death Triggered by Oxidative Stress in Pancreatic β HIT-T15 Cell
Recent studies have demonstrated that reactive oxygen species9ROS9and the resulting oxidative stress play an important role in apoptosis. Apoptosis is implicated in pathophysiology of diabetes mellitus. Antiox...
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Chapter and Conference Paper
The Suppressive Effect of Electrolyzed Reduced Water on Lipid Peroxidation
We examined the suppressive effect on lipid peroxidation of electrolyzed reduced water (ERW), which exhibited reactive oxygen species (ROS)-scavenging activity in vitro and in cultured cells. The oxidation of lin...
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Article
Anisotropic orthodontic force from the hollow super-elastic Ti-Ni alloy wire by transforming the wire cross-section
The purpose of this research was to devise a method for transforming the cross-section of the hollow super-elastic Ti-Ni alloy round wire and to examine the changes in its bending properties for clinical ortho...
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Article
Bending properties of hollow super-elastic Ti–Ni alloy wires and compound wires with other wires inserted
The purpose of this research was to investigate the possible orthodontic application of the hollow super-elastic Ti–Ni alloy wire, which was thought not only to deliver much lower and more continuous orthodont...
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Chapter
Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes
In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that...
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Chapter
Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and Regulates Gene Expression of Animal Cells
Active oxygen species are considered to cause extensive oxidative damage to biological macromolecules, which bring about a variety of diseases as well as aging. Reduced water produced near cathode during elect...
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Article
Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism
Background: Little is known about differences in the disposition kinetics and pharmacological effects on gastrin levels between lansoprazole and rabeprazole given in a repeated dosing scheme with respect to the ...
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Chapter
Anti-Oxidative Water Improves Diabetes
Electrolyzed reduced water and natural waters such as Hita Tenryosui water in Japan, Nordenau water in Germany and Tracote water in Mexico, which are known to improve various diseases, were all and- oxidative ...
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Article
Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9 * 3 allele
Objectives: Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug m...
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Article
CYP2C19 polymorphism effect on phenobarbitone
Objective: The aim of this study was to clarify the effect of genetic polymorphisms of CYP2C19 on the pharmacokinetics of phenobarbitone (PB) using a nonlinear mixed-effects model (NONMEM) analysis in Japanese a...
