73 Result(s)

Article

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation

Epigenetic gene regulation linked to oncogenic pathways is an important focus of cancer research. KDM3A, a histone H3 lysine 9 (H3K9) demethylase, is known to have a pro-tumorigenic function. Here, we showed t...

T Nakatsuka, K Tateishi, Y Kudo, K Yamamoto, H Nakagawa, H Fujiwara… in Oncogene (2017)

Chapter and Conference Paper

Estimation of Regional Groundwater System in a Granitic Body by 3D Permeable Zone Modeling and Flow Simulation

Because clarifying a regional groundwater system is required for development and management of groundwater resources, it is important to evaluate the hydraulic property of a fracture system and alteration zone...

T. Kubo, N. Matsuda, K. Kashiwaya, C. Liu… in Geostatistical and Geospatial Approaches f… (2016)

Article

Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia

Multidrug resistance protein 4 (MRP4) is involved in the efflux of nucleoside derivatives and has a role in the determination of drug sensitivity. We investigated the relationship between MRP4 genetic polymorphis...

Y Tanaka, A Manabe, H Fukushima, R Suzuki, H Nakadate… in The Pharmacogenomics Journal (2015)

Article

Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease

Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections...

T. Shigemura, Y. Nakazawa, Y. Amano, A. Sudo, M. Watanabe, M. Kobayashi… in Infection (2015)

Article

In vitro expansion of CD34⁺CD38⁻ cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia

Using serum-containing culture, we examined whether AGM-S3 stromal cells, alone or in combination with hematopoietic growth factor(s), stimulated the proliferation of CD34⁺ cells from patients with juvenile myelo...

K Sakashita, I Kato, T Daifu, S Saida, H Hiramatsu, Y Nishinaka, Y Ebihara… in Leukemia (2015)

Article

Safety, tolerability, and feasibility of antifungal prophylaxis with micafungin at 2 mg/kg daily in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

Micafungin (MCFG) is used for the prophylaxis of invasive fungal disease (IFD) after allogeneic hematopoietic stem cell transplantation (HSCT). However, the safety, efficacy, or optimal dosage/blood levels as ...

K. Yoshikawa, Y. Nakazawa, Y. Katsuyama, K. Hirabayashi, S. Saito… in Infection (2014)

Article

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

K Matsuda, Y Nakazawa, C Iwashita, T Kurata, K Hirabayashi, S Saito, M Tanaka… in Leukemia (2014)

Article

Persistent elevated C-reactive protein after treatment is an independent marker of a poor prognosis in patients with hepatocellular carcinoma

The pretreatment C-reactive protein (CRP) level is reported to be a prognostic indicator in patients with hepatocellular carcinoma (HCC).

N. Imai, A. Kinoshita, H. Onoda, A. Iwaku, M. Oishi… in Clinical and Translational Oncology (2013)

Article

Acropora recruits harbor “rare” Symbiodinium in the environmental pool

Coral–algal symbioses are essential for the survival of corals. Algal endosymbionts, specifically the dinoflagellate genus Symbiodinium, are divided into several genetic clades. The composition of Symbiodinium wi...

H. Yamashita, G. Suzuki, T. Hayashibara, K. Koike in Coral Reefs (2013)

Article

Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT

Y Nakazawa, S Saito, R Yanagisawa, T Suzuki, T Ito, F Ishida… in Bone Marrow Transplantation (2013)

Article

Successful ganciclovir therapy in a patient with human herpesvirus-6 encephalitis after unrelated cord blood transplantation: usefulness of longitudinal measurements of viral load in cerebrospinal fluid

There have been no reports of human herpesvirus-6 (HHV-6) encephalitis treatment based on both HHV-6 DNA load and the antiviral agent’s concentration in the cerebrospinal fluid (CSF).

K. Hirabayashi, Y. Nakazawa, Y. Katsuyama, T. Yanagisawa, S. Saito… in Infection (2013)

Article

Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic SCT

We investigated clinical factors that affected the clearance of tacrolimus (FK506) administered by continuous drip infusion to children who had received allogeneic hematopoietic SCT. Blood FK506 levels were me...

R Yanagisawa, Y Katsuyama, T Shigemura, S Saito, M Tanaka… in Bone Marrow Transplantation (2011)