19 Result(s)
within
K. Kohno
Biomedicine
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Article
Synaptic contacts from nodes of Ranvier in the granular layer of the frog cerebellum
The ultrastructure of nodes of Ranvier was examined in the granular layer of the cerebellum ofRana nigromaculata. Many of the nodes in the layer were modified to form synaptic contacts with dendrites, probably of...
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Article
Fine structure of the axon collaterals of Huber in frog spinal ganglia
The fine structure of intracapsular axon collaterals in the spinal ganglia ofRana nigromaculata nigromaculata has been studied. The collaterals originated from the initial tract of the axon, before its bifurcatio...
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Article
Number and polarity of the ependymal cilia in the central canal of some vertebrates
The numbers and the polarity of the ependymal cilia in the central canals of goldfish, frogs, turtles, birds, rats, and rabbits had been studied with the electron microscope. The number of cilia per cell was c...
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Article
The topographical organization of neurons in the dorsal hypothalamic area that project to the spinal cord or to the nucleus raphé pallidus in the rat
The present study was undertaken using retrograde labeling techniques to clarify whether the neurons in the dorsal hypothalamic area (DHA) that project to the spinal cord are the same as those that project to ...
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Article
Direct projection from the dorsal hypothalamic area to the nucleus raphe pallidus: a study using anterograde transport with Phaseolus vulgaris leucoagglutinin in the rat
A hypothalamic projection to the nucleus raphe pallidus of the medulla was examined using the anterograde tracing technique based on Phaseolus vulgaris leucoagglutinin (PHA-L) in the rat. After the iontophoretic ...
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Article
Descending projections from the hypothalamic paraventricular nucleus to the A5 area, including the superior salivatory nucleus, in the rat
The descending projection of the hypothalamic paraventricular nucleus (PVN) to the A5 area was elucidated using a technique that combines retrograde labeling with horseradish peroxidase (HRP), anterograde labe...
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Article
Descending input from the hypothalamic paraventricular nucleus to sympathetic preganglionic neurons in the rat
The descending projection of the hypothalamic paraventricular nucleus (PVN) to the sympathetic preganglionic neurons (SPNs) in the upper thoracic cord of the rat was studied. PVN-fibers were labeled by anterog...
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Article
Coincidence of “ladder-like patterns” in distributions of monoaminergic terminals and sympathetic preganglionic neurons in the rat spinal cord
A ladder-like pattern of distribution of sympathetic preganglionic neurons (SPNs) was compared with that of monoaminergic terminals in the upper thoracic spinal cord of the rat. SPNs were identified by a retro...
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Article
Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice
We recently reported that six 1,4-dihydropyridine derivatives out of 57 screened effectively over-came vincristine (VCR)-resistance in VCR-resistant (P388/VCR) leukaemia-bearing mice when the dihydropyridines ...
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Article
Morphology of sympathetic preganglionic neurons innervating the superior cervical ganglion in the chicken: an immunohistochemical study using retrograde labeling of cholera toxin subunit B
Preganglionic sympathetic neurons (SPNs) in the chicken were demonstrated immunohistochemically using cholera toxin subunit B (CTb) as a retrograde tracer. After injection of CTb-solution into the superior cer...
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Article
Thoracolumbar sympathetic preganglionic neurons in the dorsal commissural nucleus of the male rat: an immunohistochemical study using retrograde labeling of cholera toxin subunit B
The cell morphology of sympathetic preganglionic neurons (SPNs) in the dorsal commissural nucleus was studied by the retrograde labeling technique using cholera toxin subunit B (CTb) as a tracer. A small amoun...
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Article
Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1
Multidrug resistance phenotypes in human tumours are associated with the overexpression of the 170 kDa P-glycoprotein encoded by the multidrug resistance 1 (MDR1) gene, and also with that of the non-P-glycopro...
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Article
Oxytocinergic innervation to the upper thoracic sympathetic preganglionic neurons in the rat
A combination of retrograde cell body labeling and immunohistochemistry was employed to elucidate how oxytocinergic fibers make contact with sympathetic preganglionic neurons (SPNs) in the rat spinal cord from...
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Article
Open AccessN-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers
N-acetylgalactosaminyl transferase-3 (GalNAc-T3) is an enzyme involved in the initial glycosylation of mucin-type O-linked proteins. In the present study, we used immunohistochemistry to examine GalNAc-T3 express...
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Open AccessLow expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence
Initial glycosylation of mucin-type O-linked protein is catalysed by one of the UDP-GalNAc: polypeptide N-acetyl-galactosaminyl transferase-3 (GalNAc-T3). O-glycosylation is important in the binding of cell adhes...
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Article
Open AccessExpression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen
Y-box-binding proteins are members of the human cold-shock domain protein superfamily, which includes dbpA, dbpB/YB-1, and dbpC/contrin. dbpC/contrin is a germ cell-specific Y-box-binding protein and is sugges...
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Open AccessPolypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival
The family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) is responsible for the altered glycosylation in cancer. The purpose of our study was to investigate the clinical significance of two isofor...
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Open AccessPolypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas
The polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) family of enzymes regulates the initial steps of mucin-type O-glycosylation. N-acetylgalactosaminyltransferases might show novel patterns of GalNAc-T...
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Article
Open AccessThe combination of strong expression of ZNF143 and high MIB-1 labelling index independently predicts shorter disease-specific survival in lung adenocarcinoma
The transcription factor, zinc finger protein 143 (ZNF143), positively regulates many cell-cycle-related genes. The ZNF143 would show high expression of multiple solid tumours related closely to cancer cell gr...
