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Article
A retrospective epidemiological study of bacterial meningitis in an urban area in Belgium
In order to obtain epidemiological data on the incidence of bacterial meningitis (BM) before the systematic introduction of vaccination against Haemophilus influenzae type b, a retrospective study of 124 childre...
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Article
Anti-glomerular basement membrane glomerulopathy in a young child
We report the youngest patient with anti-glomerular basement membrane disease described in the literature to date. Age-dependent expression of the target antigen in this auto-immune disease explains the low i...
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Article
Low thyroxinaemia occurs in the majority of very preterm newborns
Transient hypothyroxinaemia with normal thyroid stimulating hormone (TSH) levels is a well-known condition in preterm neonates and is generally assumed to be a harmless epiphenomenon of prematurity. This assum...
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Article
Acute interstitial nephritis and anterior uveitis
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Article
Protein restriction in chronic renal failure
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Article
Abstracts of poster presentations
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Article
Involvement of the renal parenchyma in acute urinary tract infection: The contribution of99mTc dimercaptosuccinic acid scan
We performed99mTc dimercaptosuccinic acid (DMSA) scan and ultrasonography in 146 children during the acute phase of a proven urinary tract infection (UTI). In 99 a micturating cysto-urethrography and in 83 an int...
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Article
Idiopathic arterial calcification of infancy
We describe two twin sisters in whom calcification of different arteries was detected in the first weeks of life. Transient renal insufficiency, arterial hypertension, and skeletal abnormalities were also obse...
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Chapter
Long-Term Evolution of Type 1 Adenine Phosphoribosyltransferase (APRT) Deficiency
There are two types of inherited adenine phosphoribosyltransferase (APRT) deficiency: type I (APRT*Qo) in which enzyme activity is practically undetectable and which is seen predominantly in Caucasians, and ty...
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Article
Recurrent haemolytic uraemic syndrome and acquired hypomorphic variant of the third component of complement
In a girl with recurrent haemolytic uraemic syndrome (HUS), persistently low serum levels of C3 were found. Analysis of complement phenotype revealed a hypomorphic variant of C3 Fast in the patient (C3fS) and ...
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Article
Symmetrical necrosis of the basal ganglia in methylmalonic acidaemia
In a patient with methylmalonic acidaemia (MMAA), persistent neurological symptoms were observed in addition to the acute episodes of metabolic dysequilibrium. CT scan and magnetic resonance imaging revealed b...
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Article
Acute sodium valproate intoxication: Occurrence of renal failure and treatment with haemoperfusion-haemodialysis
In a child who probably received an overdose of sodium valproate, progressive coma, intermittent tonic-clonic seizures and anuria developed. Laboratory investigations revealed coagulopathy, anaemia and mildly ...
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Chapter
Allopurinol and Dietary Purine Affect Urinary Uric Acid but not Urinary Oxalate Levels
Previously, we and others showed that the ingestion of a non-specific high-purine diet by healthy subjects increased not only urinary uric acid, but urinary oxalate levels as well. Significant reductions in bo...
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Article
Abdominal colic due to ureteric diverticulum with stone formation
In a 15-year-old boy right lower abdominal colicky pain was caused by intermittent obstruction of the ureter by stones which had accumulated in a ureteric diverticulum. As was shown by repeated X-rays, each of...
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Article
Increased serum prolactin but normal TSH during prolonged domperidone treatment in children
The influence of the dopamine receptor blocking agent domperidone on prolactin and TSH secretion was studied in 16 infants, aged 10–360 days, who were treated for gastroesophageal reflux. The pretreatment seru...
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Article
Haemorrhagic shock and encephalopathy
Two infants are described with a fulminant disorder characterised by profound circulatory collaps and shock, generalised convulsions and unremitting coma, bleeding due to severe DIC, fever, diarrhoea, metaboli...
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Article
Benign ureteral fibrous polyp as a cause of obstruction in children
In an 11-year-old boy with intermittent colicky flank pain for several years unilateral obstruction caused by benign ureteral fibrous polyps was found. The radiologic characteristics are discussed and the need...
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Chapter and Conference Paper
Immunologically Mediated Tubulointerstitial Nephritis
Various experimental studies have shown that tubulo-interstitial nephritis (TIN) may be mediated by auto-antibodies directed against components of the tubular basement membranes (TBM), but the mechanisms of th...
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Article
Meningitis due to Haemophilus influenzae with multiple resistance to antibiotics: use of moxalactam
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Chapter
2, 8-Dihydroxyadeninuria: Or When is a Uric Acid Stone not a Uric Acid Stone?
Purine nucleotides important for normal cellular metabolism are derived endogenously from de novo synthesis and also from recycling of pre-formed purines via the so-called salvage pathway (Figure 1). The latter p...
