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Article
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats
Aim of the present study was to investigate the influence of the angiotensin II (ANG II) subtype 1 (AT1) receptor blockers fonsartan and losartan on blood pressure, cardiac -dynamics and -metabolism as well as fu...
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Chapter
Toxicology of Sulfonylureas
Since 1958, Hoechst AG, Frankfurt, and Boehringer Mannheim GmbH have synthesized and pharmacologically tested a large number of sulfonylurea analogues which elicit hypoglycemic activity in the milligram range ...
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Article
Ramipril prevents the detrimental sequels of chronic NO synthase inhibition in rats: hypertension, cardiac hypertrophy and renal insufficiency
Inhibition of the angiotensin converting enzyme (ACE) with ramipril was studied in male Wistar rats during long-term inhibition of nitric oxide (NO) synthase by NG-nitro-l-arginine methyl ester (l-NAME). Chronic ...
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Article
Prevention of the acute graft-versus-host disease (GVHD) in rats by the immunomodulating drug leflunomide
The grafting of immunocompetent allogeneic cells into MHC-discordant, genetically nonresponsive F1 hybrids of inbred rat strains consistently leads to an acute, lethal graft-versus-host disease (GVHD). The novel ...
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Article
Biophysikochemische Strukturen des glomerulären Filters
The ultrastructural and the biophysical and biochemical qualities of glomerular permeability to protein molecules are reviewed. With regard to differently located immune deposition in human glomerulonephritis,...
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Article
Endocytotic activity in epitheloid and Langhans’ giant cells
In the experimental tubulo-interstitial (anti-basement membrane) nephritis in the rat, electron microscopic studies after the in vivo microinjection of native ferritin in areas of granulomatous inflammation ne...
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Article
Cell fusion as a mechanism for the formation of giant cells (Langhans’ type)
The formation of multinuclear giant cells of the Langhans’ type in tubulo-interstitial auto-immune nephritis in the rat has been investigated by means of autoradiography.
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Article
Characterization of cells involved in the formation of granuloma
In experimental tubulo-interstitial (anti-basement membrane) nephritis of the rat, granulomatous inflammation develops around immunologically altered tubular basement membranes. The present light-and electron ...
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Chapter and Conference Paper
Tubulo-interstitielle Nierenschädigung nach Laxantienabusus
Etwa 50% aller Patienten mit chronischem Laxantienabusus weisen eine Hypokaliämie durch enterale und renale Kaliumverluste auf [1]. Begleitende Nierenfunktionseinschränkungen wurden auf eine hypokaliämische Ne...
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Article
Demonstration of percellular channels in glomerular podocytes in aminonucleoside nephrosis
Nephrotic syndrome was experimentally induced by a single i.v. injection of puromycin. Permeability of the visceral epithelial wall of glomeruli was examined with electron microscope. 30–60 seconds prior to fi...
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Article
Lipoproteins in lecithin-cholesterol-acyltransferase (LCAT)*-deficiency
The lipoproteins from two sibs with familial lecithin-cholesterol-acyltransferase(LCAT)-deficiency were further characterized. Comparatively lipoproteins from patients with secondary LCAT-deficiency were studi...
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Article
Split and extremely thin glomerular basement membranes in hereditary nephropathy (Alport's syndrome)
Alterations of the glomerular basement membrane are the earliest ultrastructurally demonstrable lesions in the course of hereditary nephropathy. The basement membranes may be either focally or diffusely thicke...
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Article
Morphologische Befunde am menschlichen M. vocalis bei Recurrensparese
In seven patients with longstanding bilateral recurrent laryngeal nerve paresis vocal muscle was excised during endolaryngeal arytaenoidectomy and examined by light- and electron microscopy.
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Article
Lipoproteins in LCAT-deficiency
Purified lipoproteins from 2 brothers and 1 unrelated male patient with lecithincholesterol-acyltransferase deficiency were investigated.
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Article
Zum Inhalt erweiterter Labyrinthspalten im proximalen Nierentubulus
Horseradish peroxidase, added to the circulation by intraaortal injection in rate, can be demonstrated in the extracellular spaces of the proximal convoluted tubules which are dilated due to the fixation. The ...
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Article
“Multitubular bodies” in the blood stream
Oval bodies (diameter approx. 0.4 µm and 0.2 µm) were demonstrated in the capillary lumen of rat organs (liver, spleen, kidney) and of human kidney. On account of the predominantly tubular structures the term “mu...
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Article
Eiweißresorptionstropfen und Lysosomen im proximalen Tubuluskonvolut der Rattenniere
Various stages of protein absorption were examined during the vacuolar phase in the proximal convoluted tubules of the rat kidney with aid of micropuncture (using the “split oil droplet method” in a modified f...
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Article
Die endocytose-phase der eiwei\resorption im proximalen nierentubulus
Using a modified “split oil droplet method” (Gertz) ferritin as a tracer protein is injected into the lumen of proximal convoluted tubules (rat kidney). After allowing varying times for absorption the tubules ...
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Chapter
Relationship Between Cell Structures of Renal Tubules and Transport Mechanisms
The use of the electron microscope in morphological research has led to substantial information concerning the fine structure of cells and hence, that of the nephron itself. New techniques have greatly facilit...
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Chapter and Conference Paper
Toxic Disturbances of Renal Functions
The prevalence and importance of the toxic nephropathies has increased considerably in the course of the last few years. This increase has created therapeutic problems in practical medicine, since the number o...
