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Article
Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
Increasing evidence suggests that environmental factors changing the normal colonisation pattern in the gut strongly influence the risk of develo** autoimmune diabetes. The aim of this study was to investiga...
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Article
Sulphated galactosylceramide
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Article
Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data
We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes.
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Article
Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies
The aim of this study was to investigate the evidence of an increased risk of childhood-onset type 1 diabetes in children born by Caesarean section by systematically reviewing the published literature and perf...
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Article
Involvement of sulfatide in beta cells and type 1 and type 2 diabetes
Mammalian tissues express β-isoforms of glycosphingolipids and, among these, sulfatide (sulphated galactosylceramide) is present in the beta cells, and it is here that the short fatty acid chain (C16) isoform ...
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Article
The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells
Aims/hypothesis. The circulating concentrations of endothelin-1 (ET-1), a peptide derived from endothelium, are increased in hypertension and diabetes. Endothelin-1 has recently been shown to be ...
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Article
Inhibition of insulin-specific autoreactive T-cells by sulphatide which is variably expressed in beta cells
Aims/hypothesis. Sulphatide and insulin are present in the secretory granules and at the surface of beta cells in islets of Langerhans. Insulin autoantibodies and T-cell reactivity against insuli...
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Article
Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells
We have monitored whole-cell and single channel ATP-sensitive K+ (KATP) currents in isolated rat glucagon-secreting pancreatic A-cells. Tolbutamide produced a concentration-dependent decrease in the whole-cell K
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells
A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes ...
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Article
GAD65 autoantibodies in women with gestational or insulin dependent diabetes mellitus diagnosed during pregnancy
We have studied the presence of GAD65 autoantibodies in women with insulin-dependent diabetes mellitus (IDDM) (n = 28) or gestational diabetes (GDM) (n = 139) diagnosed during pregnancy and investigated the temp...
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Chapter
Diabetes Diagnosed During Pregnancy: Follow-up Studies
Diabetes diagnosed during pregnancy is clinically represented by several categories of patients. Thus, according to the latest recommendation gestational diabetes mellitus is defined as carbohydrate intoleranc...
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Article
Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals
A group of 36 diabetes-prone BB Wistar rats were given prophylactic insulin treatment with heat-treated bovine ultralente insulin (15 IU · kg−1 · day−1) from 50 to 142 days of age. The incidence of Type 1 (insuli...
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Article
T lymphocyte subsets in patients with newly diagnosed Type 1 (insulin-dependent) diabetes: A prospective study
T lymphocyte subsets in peripheral blood from 11 newly diagnosed Type 1 (insulin-dependent) diabetic patients were studied prospectively at three time intervals: as soon as possible after diagnosis, 3 weeks an...
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Article
Virus-induced diabetes mellitus in mice and the thymus-dependent immune system
The present study concerns the effect of the experimental diabetogenic encephalomyocarditis (EMC) virus on normal and athymic nude mice of BALB/c origin. The effect of simultaneous immunosuppressive pharmacolo...
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Article
Incidence, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus in Denmark
The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970–1974. The j.i.d.m...
