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Article
Immunomodulation with thymopentin:in vitro studies
Immunomodulation is interpreted as a temporary alert in a certain part of the immune system. The activation of immune competent cells is presented as a possible basic mechanism of this phenomenon. In the absen...
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Chapter and Conference Paper
Immunomodulation as a Potential Therapeutic Approach in Immunodeficiencies
The term immunomodulation has started to come into use through an increasing number of experiments showing that substances of various origin can stimulate as well as inhibit immune responses induced by a prima...
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Article
Thymopentin treatment in aids and pre-aids patients
Three pilot studies testing thymopentin in AIDS patients are presented. One study included 5 patients with the full-blown syndrome, all treated with 50 mg thymopentin 3 times a week by intravenous slow infusio...
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Article
Thymopentin in active rheumatoid arthritis
The present paper reports on 16 patients with active rheumatoid arthritis who were treated with thy-mopentin administered as intravenous prolonged injections (one push of 5 mg every minute for 10 min) three ti...
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Article
Rationale for thymopentin as therapeutic agent in rheumatoid arthritis
Etiology and pathogenesis of rheumatoid arthritis (RA) is reviewed, with special emphasis on immunological factors. A common feature in active RA seems to be the decreased T cell suppressor/cytotoxic response,...
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Article
Modulation of immune response in aged humans through different administration modes of thymopentin
Thymopentin, a synthetic pentapeptide corresponding to the active site of thymopoietin, has been shown to restore antibody production in old mice. A decrease in immune response can also be observed in elderly ...
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Article
Thymopentín as adjuvant to hepatitis vaccination
The influence of adjuvant thymopentin therapy on the effect of vaccination with HB-Vax was investigated in three independent double-blind studies in which threee different time/dose schedules of the adjuvant t...
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Article
Thymopentin treatment in a patient with pluriorifieial Pyoderma vegetans
This paper presents longitudinal clinical and immunological findings in a patient with a life-long history of pluriorificial pyoderma vegetans, a disease characterized by a distinct immunodeficiency of T lymph...
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Article
Some observations on various dose regimens of thymopentin treatment in rheumatoid arthritis
Eight patients suffering from active rheumatoid arthritis were treated with thymopentin, 50 mg, administered as fractionated intravenous infusion over 10 min 3 times weekly for 3–20 weeks. Seven patients exper...
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Article
Confirmative study of the effectiveness of thymopentin in active rheumatoid arthritis
Forty-one patients with active rheumatoid arthritis entered a controlled double-blind randomized study. Of these patients, 21 received prolonged intravenous injections (10min) of thymopentin 50 mg three times ...
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Article
Thymopentin as adjuvant therapy to hepatitis B Vaccination in formerly non- or hyporesponding hemodialysis patients
Thirteen patients who were on chronic hemodialysis for renal failure received booster vaccination with 40 μg HB-Vax while receiving thymopentin as adjuvant therapy. A 50-mg dose of thymopentin was administered...
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Article
Prevention of recurrences in frequently relapsing herpes labialis with thymopentin a randomized double-blind placebo-controlled multicenter study
The present randomized, placebo-controlled double-blind multicenter study included a population of 36 subjects with frequent recurrences (at least once a month) of herpes labialis. Most of the patients had fai...
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Article
Effect of thymopentin on the mortality and immune response after an experimental herpes simplex infection in mice
The effect of thymopentin on the mortality rate of mice treated with lethal doses (LD90) of herpes virus 2 and on the cytotoxic T cell activity after sublethal doses (LD10) of herpes virus was investigated in two...
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Article
In vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte cultures
Peripheral human blood lymphocytes from healthy blood donors were investigated in vitro to observe the influence of different doses of thymopentin on nonstimulated proliferation, candidin-stimulated proliferat...
