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    Article

    Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia

    Acute myeloid leukemia (AML) is an aggressive and lethal blood cancer originating from rare populations of leukemia stem cells (LSCs). AML relapse after conventional chemotherapy is caused by a remaining popul...

    S Fujita, D Honma, N Adachi, K Araki, E Takamatsu, T Katsumoto, K Yamagata in Leukemia (2018)

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    Article

    Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

    Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched mode...

    M Koyama, D Hashimoto, K Nagafuji, T Eto, Y Ohno, K Aoyama in Bone Marrow Transplantation (2014)

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    Chapter and Conference Paper

    Supporting System for Tour Lineup Design based on Tour Service Modeling

    This paper proposes a computer aided design method of package tours that meets various tourists’ favors while controlling cost. Tour service is modeled as network that comprises activity, place, capability and...

    K. Oizumi, Y. Meguro, C. X. Wu, K. Aoyama in The Philosopher's Stone for Sustainability (2013)

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    Article

    Impurity Activation in N+ Ion-Implanted 6H-SiC with Pulsed Laser Annealing Method

    We have succeeded in pulsed laser annealing of N+ ion-implanted n-type 6H-SiC for increasing the carrier density near surface in order to decrease contact resistance, which induces little redistribution of implan...

    O. Eryu, K. Aoyama, K. Abe, K. Nakashima in MRS Online Proceedings Library (2011)

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    Article

    Vortex Core Transitions in Superfluid 3He in Uniaxially Anisotropic Aerogel

    Vortex core transitions (VCTs) in the superfluid phases of liquid 3He in uniaxially stretched and compressed aerogels are theoretically investigated. Uniaxial deformation imposed on the aerogel alters superfluid ...

    K. Aoyama, R. Ikeda in Journal of Low Temperature Physics (2010)

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    Article

    Dermatophyte Infections in Cairo, Egypt

    In this study, we examined dermatophyte infections in patients referred to the Department of Dermatology, EL-Houd El-Marsoud Hospital, Cairo, during March 2004 to June 2005. Of 506 patients enrolled in this in...

    S. M. Zaki, N. Ibrahim, K. Aoyama, Y. M. Shetaia, K. Abdel-Ghany in Mycopathologia (2009)

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    Article

    Regulation of STAT3-mediated signaling by LMW-DSP2

    Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors, and has been reported to be constitu...

    Y Sekine, S Tsuji, O Ikeda, N Sato, N Aoki, K Aoyama, K Sugiyama, T Matsuda in Oncogene (2006)

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    Article

    Two cases of left-sided gastroschisis: review of the literature

    In gastroschisis, the opening is almost always to the right of the umbilicus, although eight cases of left-sided gastroschisis have been reported in the literature. We encountered two additional cases of left-...

    H. Yoshioka, K. Aoyama, Y. Iwamura, T. Muguruma in Pediatric Surgery International (2004)

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    Article

    N-Methylation ability for azaheterocyclic amines is higher in Parkinson's disease: nicotinamide loading test

    The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) leads to the hypothesis that Parkinson's disease (PD) is may be initiated or precipitated by endogenous toxins by the mechanism similar to ...

    K. Aoyama, K. Matsubara, K. Okada, S. Fukushima in Journal of Neural Transmission (2000)

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    Article

    Pharmacokinetics of [125I]-recombinant human interleukin-11:

    Placental transfer and excretion into milk of [125I]-rhIL-11 (recombinant human interleukin-11) after subcutaneous administration in female rats were investigated. After administration of [125I]-rhIL-11 to rats o...

    T. Uchida, K. Aoyama, K. Mori, T. Usui in European Journal of Drug Metabolism and Ph… (1998)

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    Article

    Pharmacokinetics of [125I]-recombinant human interleukin-11: 1. Absorption, distribution and excretion after subcutaneous administration to male rats

    Absorption, distribution, metabolism and excretion of [125I]-rhIL-11 (recombinant human interleukin-11) after subcutaneous administration in rats were investigated. After a single administration, the concentratio...

    T. Uchida, K. Aoyama, K. Mori, T. Usui in European Journal of Drug Metabolism and Ph… (1998)

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    Article

    Copper damascene using low dielectric constant fluorinated amorphous carbon interlayer

    We have developed a new interconnect technique using a low-k (et,=2.5) organic interlayer (fluorinated amorphous carbon: a-C:F) and a low-resistivity metal line (copper). The new technique attains a duction in bo...

    Y. Matsubara, K. Endo, M. Iguchi, N. Ito, K. Aoyama in MRS Online Proceedings Library (1998)

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    Article

    Model for evaluating cross-sensitivity of DNBS with DNCB using hapten-stimulated in vitro interleukin-2 production by murine lymph node cells

    B. Xu, K. Aoyama, T. Matsuyama in Bulletin of Environmental Contamination an… (1995)

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    Article

    Respiratory effects and skin allergy in workers exposed to tetrachloroisophthalonitrile

    J. Huang, K. Aoyama, A. Ueda, T. Matsushita in Bulletin of Environmental Contamination an… (1995)

  15. No Access

    Chapter and Conference Paper

    A Method for Extracting the Threshold Voltage of MOSFETs Based on Current Components

    A new method for extracting the threshold voltage of MOSFETs is presented. The threshold voltage is the gate voltage at which the second difference of the logarithm of the drain current takes a minimum value. ...

    K. Aoyama in Simulation of Semiconductor Devices and Processes (1995)

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    Article

    Provocation of respiratory allergy in guinea pigs following inhalation of free toluene diisocyanate

    An animal exposure experiment which simulated a workplace exposure situation was made to compare toluene diisocyanate (TDI) concentrations which resulted in antibody production with those which elicited pulmon...

    K. Aoyama, J. Huang, A. Ueda, T. Matsushita in Archives of Environmental Contamination an… (1994)

  17. No Access

    Chapter and Conference Paper

    Purification and Endotoxin-Like Bioactivities of a Novel Amphiphile from Mycobacterium bovis BCG

    In the previous study (Ikeda-Fujita et al., 1987b, 1987c) we demonstrated that a lipopolysaccharide fraction prepared from ’delipidated’ cells of Mycobacterium bovis BCG by extraction with 95% phenol/water (Westp...

    S. Kotani, A. Nagao, T. Tamura, H. Okamura in Immunotherapeutic Prospects of Infectious … (1990)

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    Article

    Holes in a stearic acid monolayer observed by dark-field electron microscopy

    The structure and behaviour of surface monolayers have been extensively studied for the past few decades, leading to practical applications to electronic devices as well as to biomimetic study. The basic conce...

    N. Uyeda, T. Takenaka, K. Aoyama, M. Matsumoto, Y. Fujiyoshi in Nature (1987)