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  1. Article

    Open Access

    Changing presentation of prostate cancer in a UK population – 10 year trends in prostate cancer risk profiles in the East of England

    Prostate cancer incidence is rising in the United Kingdom but there is little data on whether the disease profile is changing. To address this, we interrogated a regional cancer registry for temporal changes i...

    D C Greenberg, K A Wright, A Lophathanon, K R Muir… in British Journal of Cancer (2013)

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  2. No Access

    Article

    Modeling of discharges in spatially charged dielectrics

    A stochastic-deterministic model of a discharge induced by space charge in dielectric is developed. The spatiotemporal and current characteristics of the discharge are simulated numerically. The simulation res...

    M. D. Noskov, A. S. Malinovskii, C. M. Cooke, K. A. Wright… in Technical Physics (2002)

  3. No Access

    Article

    The in vitro effects and cross-resistance patterns of some novel anthracyclines

    A range of new anthracyclines, structurally related to adriamycin (ADM), has been synthesised and studied in vitro. Three compounds described in this paper (Ro 31-1215; Ro 31-1741; Ro 31-2035) are all 4-demethoxy...

    P R Twentyman, N E Fox, K A Wright, P Workman, M J Broadhurst… in British Journal of Cancer (1986)

  4. No Access

    Article

    Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells

    We have produced adriamycin (ADM)-resistant variants of the human lung cancer cell lines NCI-H69 (small cell), MOR (adenocarcinoma) and COR-L23 (large cell) but have failed to produce resistant variants of two...

    P R Twentyman, N E Fox, K A Wright, N M Bleehen in British Journal of Cancer (1986)

  5. No Access

    Article

    The effects of α and γ interferons on human lung cancer cells grown in vitro or as xenografts in nude mice

    We have compared the effects of alpha and recombinant gamma interferons (IFNs) on the growth of human lung cancer cell lines in vitro. There was a diversity of response amongst the lines studied, the most sensiti...

    P R Twentyman, P Workman, K A Wright, N M Bleehen in British Journal of Cancer (1985)

  6. No Access

    Article

    The response of tumour cells to radiation and cytotoxic drugs– A comparison of clonogenic and isotope uptake assays

    We have carried out a series of experiments to compare the response to radiation and drugs of cells disaggregated from solid tumours as assayed by clonogenic survival and by an isotope incorporation method. Th...

    P R Twentyman, G A Walls, K A Wright in British Journal of Cancer (1984)

  7. No Access

    Article

    Patterns of cross-sensitivity in the responses of clonal subpopulations isolated from the RIF-1 mouse sarcoma to selected nitrosoureas and nitrogen mustards

    The response of clonal subpopulations isolated from the RIF-1 mouse sarcoma to melphalan treatment is independent of cell ploidy, whereas a clear relationship exists between ploidy and cell sensitivity to CCNU...

    J G Reeve, K A Wright, P Workman in British Journal of Cancer (1984)

  8. No Access

    Article

    Response to X-radiation and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated from RIF-1 mouse sarcoma

    Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and...

    J G Reeve, K A Wright, P R Twentyman in British Journal of Cancer (1983)

  9. No Access

    Article

    Ein Bewegungsviseosimeter (kinematie viseometer) für flüssige Asphaltprodukte

    A. P. Anderson, K. A. Wright, R. L. Griffin in Zeitschrift für analytische Chemie (1942)