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Article
Open AccessReversal of freshening trend of Antarctic Bottom Water in the Australian-Antarctic Basin during 2010s
The Antarctic continental margin supplies the densest bottom water to the global abyss. From the late twentieth century, an acceleration in the long-term freshening of Antarctic Bottom Waters (AABW) has been d...
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Article
Open AccessPReS-FINAL-2166: Long-term safety and effectiveness of anti-interleukin-6 receptor monoclonal antibody, tocilizumab, in patients with systemic juvenile idiopathic arthritis in Japan
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Article
Open AccessPReS-FINAL-2189: Tocillizumab for patients with takayasu arteritis in childhood refractory to conventional therapy
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Article
Open AccessPReS-FINAL-2172: Efficacy of corticosteroids and intravenous cyclophosphamide for patients with juvenile systemic sclerosis
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Article
Open AccessPReS-FINAL-2110: Tocilizumab for patients with oligoarticular juvenile idiopathic arthritis refractory to conventional therapy
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Article
Open AccessPW02-024 - A case of candle syndrome treated with thalidomide
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Article
Erratum to: HbA1c variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2
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Article
HbA1c variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2
The aim of this study was to examine the association between HbA1c variability and the development of microalbuminuria as defined by an albumin/creatinine ratio ≥3.4 mg/mmol (≥30 mg/g) in at least two of three co...
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Article
Open AccessTool fabrication system for micro/nano milling—function analysis and design of a six-axis Wire EDM machine
The dies or molds used for the fabrication of micro products usually are made of ultra-hard materials such as tungsten carbide or silicon carbide and have sophisticated three-dimensional geometries. Such kind ...
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Article
Open AccessErratum: Uracil-tegafur and tamoxifen versus cyclophosphamide, methotrexate, fluorouracil, and tamoxifen in postoperative adjuvant therapy for stage I, II, or IIIA lymph node-positive breast cancer: a comparative study
Correction to: British Journal of Cancer (2009) 101, 598–604. doi:10.1038/sj.bjc.6605218 www.bjcancer.com Upon publication of this paper in Volume 101, the authors noticed an error in the data contained within...
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Article
Open AccessUracil-tegafur and tamoxifen vs cyclophosphamide, methotrexate, fluorouracil, and tamoxifen in post-operative adjuvant therapy for stage I, II, or IIIA lymph node-positive breast cancer: a comparative study
It has been reported that treatment with uracil-tegafur (UFT) has shown significantly better survival and relapse-free survival (RFS) than surgery alone. Therefore, we compared UFT with a combination therapy o...
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Article
Open AccessGrowth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant
cJun, a major constituent of AP-1 transcription factor transducing multiple mitogen growth signals, is frequently overexpressed in non-small cell lung cancers (NSCLCs). The purpose of this study is to determin...
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Article
Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A
Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II. To gain more insight into the physiological functions of Elongin A, we generated El...
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Article
Open AccessDifferences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach
Adenocarcinoma of the gastric cardia (C-Ca) is possibly a specific subtype of gastric carcinoma. The purpose of this study was to clarify the differences in the clinicopathological characteristics between C-Ca...
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Article
Open AccessReply: Appropriate prospective trials are warranted to determine differences between exon 19 deletions and L858R EGFR mutations in non-small cell lung cancer
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Article
Open AccessA phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
Retrospective analysis has shown that activating mutations in exons 18–21 of the epidermal growth factor receptor (EGFR) gene are a predictor of response to gefitinib. We conducted a phase II trial to evaluate...
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Chapter and Conference Paper
A Method for the Mixed Discrete Non-Linear Problems by Particle Swarm Optimization
An approach for the Mixed Discrete Non-Linear Problems (MDNLP) by Particle Swarm Optimization is proposed. The penalty function to handle the discrete design variables is employed, in which the discrete design...
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Chapter and Conference Paper
Optimum Design of Cooling Pipe Systems by Branching Tree Model in Nature
This paper suggests an innovative design methodology of heat transfer system based on a so-called adaptive growth law, which is an essential optimum growth rule of branch systems in nature. The branch systems ...
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Chapter and Conference Paper
Optimization of Cooling Pipe System of Plastic Molding
In a plastic injection molding, design of cooling pipe system is one of the important problems to reduce internal residual stresses of molded products. If plastic materials in the injection molding die are coo...
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Article
Open AccessGastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions-
Both gastric and intestinal phenotypic markers are known to be expressed in gastric carcinomas, irrespective of their histologic type. In the present study, the relation between gastric and intestinal phenotyp...
