Skip to main content

2 Result(s)

within K Shin-ya Remove this filter

and

  1. No Access

    Article

    Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia

    The telomerase complex is responsible for telomere maintenance and represents a promising neoplasia therapeutic target. Recently, we have demonstrated that treatment with a G-quadruplex-interactive agent, telo...

    T Tauchi, K Shin-ya, G Sashida, M Sumi, S Okabe, J H Ohyashiki, K Ohyashiki in Oncogene (2006)

  2. No Access

    Article

    G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells

    Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the telomerase inhibitor telomes...

    H Tahara, K Shin-ya, H Seimiya, H Yamada, T Tsuruo, T Ide in Oncogene (2006)