17 Result(s)
within
Junzo Kamei
Biomedicine
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Article
Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice
While patients with cancer show a higher prevalence of psychiatric disorders than the general population, the mechanism underlying this interaction remains unclear. The present study examined whether tumor-bea...
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Article
Open AccessPlacental extract suppresses lipid droplet accumulation by autophagy during the differentiation of adipose-derived mesenchymal stromal/stem cells into mature adipocytes
Placental extract, which contains various bioactive compounds, has been used as traditional medicine. Many studies have demonstrated additional applications of placental extract and provided a scientific basis...
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Article
Open AccessEffect of different shielding conditions on the stability of Cisplatin
Because cisplatin (CDDP) decreases upon light exposure, it is necessary to prevent such exposure during administration. However, the shielding conditions employed are not uniform. Therefore, in this study, we ...
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Article
Interference of Skin Scratching Attenuates Accumulation of Neutrophils in Murine Allergic Contact Dermatitis Model
We recently reported that swelling resulting from 2,4,6-trinitrochlorobenzene (TNCB) challenge might be associated with recruitment of neutrophils. However, it is not known whether neutrophil recruitment is af...
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Article
Response on: Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice (Miyata S. et al., Psychopharmacology, 2009)
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Article
Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice
The traditional antihistamine chlorpheniramine ameliorates panic attacks, phobias, and lowered mood, and this therapeutic effect is independent of the blockade of histamine H1 receptors. Since chlorpheniramine in...
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Article
Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats
It has been reported that many of the behavioral and serotonergic neuronal changes observed in olfactory bulbectomy (OBX) were improved by subchronic administration of a variety of antidepressants.
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Article
ROCK inhibition produces anxiety-related behaviors in mice
The role of Rho/Rho-associated kinase (ROCK) in regulating dendritic and axonal morphology during development has gained much attention. Very little is known, however, about the role of the Rho/ROCK pathway in...
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Article
Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice
We previously reported that the head-twitch responses induced by the 5-HT2 receptor agonist (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) (DOI-HTRs) were decreased in streptozotocin-induced diabetic mice.
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Article
Role of δ-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats
Recent studies have shown that endogenous opioid systems are associated with the regulation of emotional responses. In particular, it has been reported that δ-opioid receptors act naturally to inhibit stress a...
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Article
Diabetes inhibits the DOI-induced head-twitch response in mice
Clinical studies suggest that the prevalence of psychiatric disorders is higher in diabetic patients than in the general population. It has been reported that central serotonin2A (5-HT2A) receptors may be involve...
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Article
Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice
Little information is available about the interaction between dihydrocodeine and second-generation antihistamine drugs such as cetirizine and ebastine, with particular reference to the rewarding effect of dihy...
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Article
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice
To test our hypothesis that the abnormally low efficacy of μ-opioid agonists in diabetic mice may be due to functional changes in ATP-sensitive potassium channels, we evaluated the effects of cromakalim on the...
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Article
The effect of chronic treatment with naltrindole, a selective δ-opioid antagonist, on μ-opioid receptor-mediated antinociception in diabetic mice
The effects of chronic treatment with naltrindole (NTI), a selective δ-opioid receptor antagonist, on the antinociceptive effects of μ-opioid agonists, such as morphine and [D-Ala2,N-MePhe4, Gly-ol5]enkephalin (D...
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Article
δ-Opiod receptor-mediated forced swimming stress-induced antinociception in the formalin test
Forced swimming stress-induced antinociception (FSSIA) was assessed using the formalin test. Male ICR mice, weighing about 30 g, were forced to swin in water at 20°C for 3 min. In unstressed mice, SC injection...
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Article
Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice
ICV cromakalim, a K+ channel opener, produced antinociception. This effect was completely antagonized by ICV glibenclamide, a selective adenosine triphosphate-sensitive K+ channel (KATP channel) blocker. Furtherm...
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Article
Involvement of µ-opioid receptors in the antitussive effects of pentazocine
The effect of pentazocine on the capsaicininduced cough reflex in rats was investigated. Intraperitoneal injection of pentazocine, in doses from 1 to 10 mg/kg, significantly decreased the number of coughs in a...
