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Open AccessA polymeric nanocarrier that eradicates breast cancer stem cells and delivers chemotherapeutic drugs
Drug nanocarriers can markedly reduce the toxicities and side effects of encapsulated chemotherapeutic drugs in the clinic. However, these drug nanocarriers have little effect on eradicating breast cancer stem...
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Article
Open AccessGenome-wide identification of RNA recognition motif (RRM1) in Brassica rapa and functional analysis of RNA-binding protein (BrRBP) under low-temperature stress
The RNA recognition motif (RRM) is primarily engaged in the processing of mRNA and rRNA following gene transcription as well as the regulation of RNA transport; it is critical in preserving RNA stability.
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Article
Open AccessPhase I study of A166, an antibody‒drug conjugate in advanced HER2-expressing solid tumours
In this phase I study, the safety, pharmacokinetics, and antitumour activity of the HER2-targeted antibody–drug conjugate A166 were evaluated in patients with HER2-expressing advanced solid tumours. Patients w...
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Open AccessAuthor Correction: iTRAQ-based quantitative proteome analysis insights into cold stress of Winter Rapeseed (Brassica rapa L.) grown in the field
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Open AccessPCSK9 inhibitor recaticimab for hypercholesterolemia on stable statin dose: a randomized, double-blind, placebo-controlled phase 1b/2 study
Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab in patients ...
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Open AccessiTRAQ-based quantitative proteome analysis insights into cold stress of Winter Rapeseed (Brassica rapa L.) grown in the field
Winter rapeseed (Brassica rapa L.) is a major oilseed crop in Northern China, where its production was severely affected by chilling and freezing stress. However, not much is known about the role of differentiall...
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Article
Open AccessEcological and economic benefits of planting winter rapeseed (Brassica rapa L.) in the wind erosion area of northern China
Winter and early spring wind soil erosion have considerable impacts on ecosystems, human well-being and agricultural production in the low precipitation zones of northern China. Little is known about the impac...
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Open AccessFusion bonding and microstructure formation in TiB2-based ceramic/metal composite materials fabricated by combustion synthesis under high gravity
The novel ceramic/metal composite materials were successfully fabricated by combustion synthesis in high gravity field. In this paper, the Ti-B4C was selected as the main combustion reaction system to obtain TiB2
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Effect of low sodium intake and β-blockade on renin synthesis and secretion in mice with unilateral ureteral ligation
We previously reported that sodium depletion increased renin secretion from the normal kidney in mice. We postulated that the combined procedures of sodium depletion and β-adrenoceptor blockade would affect th...