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Article
Open AccessA polymeric nanocarrier that eradicates breast cancer stem cells and delivers chemotherapeutic drugs
Drug nanocarriers can markedly reduce the toxicities and side effects of encapsulated chemotherapeutic drugs in the clinic. However, these drug nanocarriers have little effect on eradicating breast cancer stem...
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Article
Open AccessGenome-wide identification of RNA recognition motif (RRM1) in Brassica rapa and functional analysis of RNA-binding protein (BrRBP) under low-temperature stress
The RNA recognition motif (RRM) is primarily engaged in the processing of mRNA and rRNA following gene transcription as well as the regulation of RNA transport; it is critical in preserving RNA stability.
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Article
Open AccessPhase I study of A166, an antibody‒drug conjugate in advanced HER2-expressing solid tumours
In this phase I study, the safety, pharmacokinetics, and antitumour activity of the HER2-targeted antibody–drug conjugate A166 were evaluated in patients with HER2-expressing advanced solid tumours. Patients w...
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Article
SGLT-2 inhibitors and euglycemic diabetic ketoacidosis/diabetic ketoacidosis in FAERS: a pharmacovigilance assessment
To investigate the main feature and the association between euglycemic diabetic ketoacidosis (euDKA) /diabetic ketoacidosis (DKA) and sodium-dependent glucose transporters 2 inhibitors (SGLT-2i) from the FDA a...
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Article
Open AccessAuthor Correction: iTRAQ-based quantitative proteome analysis insights into cold stress of Winter Rapeseed (Brassica rapa L.) grown in the field
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Article
Open AccessPCSK9 inhibitor recaticimab for hypercholesterolemia on stable statin dose: a randomized, double-blind, placebo-controlled phase 1b/2 study
Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab in patients ...
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Article
Open AccessiTRAQ-based quantitative proteome analysis insights into cold stress of Winter Rapeseed (Brassica rapa L.) grown in the field
Winter rapeseed (Brassica rapa L.) is a major oilseed crop in Northern China, where its production was severely affected by chilling and freezing stress. However, not much is known about the role of differentiall...
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Article
Phosphotungstic acid encapsulated in USY zeolite as catalysts for the synthesis of cyclohexylbenzene
In this work, a new type of catalyst, USY-HPW, was successfully prepared by encapsulating phosphotungstic acid (HPW) into ultra-stable Y zeolite (USY). The obtained catalyst USY-HPW was characterized by variou...
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Article
Concentration-Dependent High-Temperature Deformation Mechanism of Hexagonal Close-Packed Ti-Al Alloys
The dependence of Al alloying on the high-temperature deformation physics of Ti-Al alloys was investigated in the present study. The mechanisms of planar dislocation slip, enhanced 〈c + a〉 activity and stacking f...
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Article
Dependence of Nb do** on microstructure and mechanical properties of Al2O3/Ti3SiC2 composites
In this work, the Al2O3/Ti3SiC2 composites with different Nb do** amounts (0–5 vol%) were prepared by vacuum hot pressing sintering (30 MPa, 1450 for 1 h). Various tests and characterization had been performed ...
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Chapter and Conference Paper
Learning Differential Diagnosis of Skin Conditions with Co-occurrence Supervision Using Graph Convolutional Networks
Skin conditions are reported the 4 \(^\text {th}\) ...
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Article
Open AccessEcological and economic benefits of planting winter rapeseed (Brassica rapa L.) in the wind erosion area of northern China
Winter and early spring wind soil erosion have considerable impacts on ecosystems, human well-being and agricultural production in the low precipitation zones of northern China. Little is known about the impac...
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Article
On the Enhanced Deformability of Brittle Intermetallics Through the Design of Heterogeneous Multi-layered Structure
Industrial manufacturing, forming, and application of brittle materials such as Ti3Al intermetallic compounds are influenced by their poor plastic deformability. For evading such a dilemma, we propose a heterogen...
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Chapter and Conference Paper
Weakly- and Semi-supervised Graph CNN for Identifying Basal Cell Carcinoma on Pathological Images
Deep learning has been used to identify Basal Cell Carcinoma (BCC) from pathology images. The traditional patch-based strategy has the problem of integrating patch level information into the whole image level...
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Article
Risk of fatigue in cancer patients receiving anti-EGFR monoclonal antibodies: results from a systematic review and meta-analysis of randomized controlled trial
To evaluate the association between fatigue and anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR MAbs), we conducted the first meta-analysis to access the incidence and risk of fatigue as...
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Article
Intrinsic Properties and Structure of AB2 Laves Phase ZrW2
Using the first-principle calculations along with the quasi-harmonic Debye model, we explore the structural, thermodynamic, mechanical, and electronic properties of ZrW2 intermetallic considering temperature or p...
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Article
Ethical off-label drug-use: Need for a rethink?
Off-label drug use is unavoidable, especially in children. Legal justice originates from ethical justice; therefore, ethical off-label drug use can be considered legal. We share our successful experiences with...
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Article
Combustion Synthesis of TiB2-TiC/42CrMo4 Composites with Gradient Joint Prepared in Different High-Gravity Fields
The novel TiB2-TiC/42CrMo4-laminated composite materials were successfully fabricated by combustion synthesis in different high-gravity fields. This ceramic/metal composite material possesses continuously graded ...
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Article
Open AccessFusion bonding and microstructure formation in TiB2-based ceramic/metal composite materials fabricated by combustion synthesis under high gravity
The novel ceramic/metal composite materials were successfully fabricated by combustion synthesis in high gravity field. In this paper, the Ti-B4C was selected as the main combustion reaction system to obtain TiB2
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Chapter and Conference Paper
Study on Tourism E-Commerce Market in China
With E-commerce and tourism develop rapidly in China, understanding of Chinese online travellers is required. This article investigates psychology and motiviation in tourism e-commerce, then an empirical study...
