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  1. Article

    Open Access

    Mechanisms of action and resistance in histone methylation-targeted therapy

    Epigenomes enable the rectification of disordered cancer gene expression, thereby providing new targets for pharmacological interventions. The clinical utility of targeting histone H3 lysine trimethylation (H3...

    Makoto Yamagishi, Yuta Kuze, Seiichiro Kobayashi, Makoto Nakashima… in Nature (2024)

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  2. No Access

    Article

    The clinical benefit of acute GVHD depends on the age at transplantation in patients with adult T-cell leukemia–lymphoma on behalf of the ATL Working Group of the Japan Society for Transplantation and Cellular Therapy

    Shigeo Fuji, Yoshitaka Inoue, Junya Makiyama, Nobuaki Nakano… in Bone Marrow Transplantation (2023)

  3. No Access

    Article

    Circulating cell-free DNA in the peripheral blood plasma of patients is an informative biomarker for multiple myeloma relapse

    Multiple myeloma (MM) is an incurable hematological malignancy. Despite the introduction of several novel drugs, most patients relapse. Biomarkers to identify the early signs of relapse will make it possible t...

    Hiroshi Yasui, Masayuki Kobayashi, Kota Sato… in International Journal of Clinical Oncology (2021)

  4. Article

    Open Access

    Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

    Subclonal genetic heterogeneity and their diverse gene expression impose serious problems in understanding the behavior of cancers and contemplating therapeutic strategies. Here we develop and utilize a captur...

    Makoto Yamagishi, Miyuki Kubokawa, Yuta Kuze, Ayako Suzuki… in Nature Communications (2021)

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  5. No Access

    Article

    Clinical features and outcomes of adult Langerhans cell histiocytosis: a single-center experience

    Langerhans cell histiocytosis (LCH) is a clonally expanding neoplasm characterized by the accumulation of CD1a + CD207 + myeloid dendritic cells. As LCH is a rare disease and is presumed to mainly affect child...

    Masayuki Kobayashi, Shohei Ando, Toyotaka Kawamata… in International Journal of Hematology (2020)

  6. No Access

    Article

    Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation

    Mitsuhito Hirano, Koji Jimbo, Miho Ogawa, Kiyosumi Ochi… in Bone Marrow Transplantation (2018)

  7. No Access

    Article

    Treatment outcome of elderly patients with aggressive adult T cell leukemia-lymphoma: Nagasaki University Hospital experience

    VCAP (vincristine, cyclophosphamide, doxorubicin, and prednisone)-AMP (doxorubicin, ranimustine, and prednisone)-VECP (vindesine, etoposide, carboplatin, and prednisone) is a standard regimen for aggressive ad...

    Junya Makiyama, Yoshitaka Imaizumi, Hideki Tsushima… in International Journal of Hematology (2014)

  8. No Access

    Article

    Serum amyloid A is a useful marker to evaluate the disease activity of Takayasu’s arteritis

    Takayasu’s arteritis (TA) is a rare large vessel vasculitis that is difficult to diagnose in the early stages. Therefore, it is also very difficult to manage and prevent irreversible vascular damage in TA. A 1...

    Tomohiro Koga, Yuichiro Nishino, Junya Makiyama… in Rheumatology International (2010)