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Article
Research codes and contracts do not guarantee equitable research with Indigenous communities
Research codes and contracts have been developed to protect Indigenous and marginalized peoples from exploitation and to promote inclusion, so that research will become more beneficial to them. We highlight th...
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Article
Open AccessCRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension
Patients with pulmonary arterial hypertension (PAH) carrying bone morphogenetic protein receptor type 2 (Bmpr2) mutations present earlier with severe hemodynamic compromise and have poorer survival outcomes than ...
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Article
Open AccessLung damage created by high tidal volume ventilation in rats with monocrotaline-induced pulmonary hypertension
Rats with chronic hypoxia-induced non-inflammatory pulmonary hypertension (PH) are resistant to ventilator-induced lung injury. We investigated the effect of high tidal volume ventilation in another model of P...
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Article
Open AccessModel difference in the effect of cilostazol on the development of experimental pulmonary hypertension in rats
Preventing pulmonary vascular remodeling is a key strategy for pulmonary hypertension (PH). Causes of PH include pulmonary vasoconstriction and inflammation. This study aimed to determine whether cilostazol (C...
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Article
Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats
The purpose of the present study was to determine if sarpogrelate hydrochloride (SPG), a serotonin 5HT2A receptor antagonist, prevented the development of chronic hypoxia-induced pulmonary hypertension (PH) a...
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Article
Open AccessThrombomodulin protects against lung damage created by high level of oxygen with large tidal volume mechanical ventilation in rats
Ventilator-induced lung injury (VILI) is associated with inflammatory responses in the lung. Thrombomodulin (TM), a component of the coagulation system, has anticoagulant and anti-inflammatory effects. We hypo...
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Article
Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension
The purpose of the present study was to investigate whether thrombomodulin (TM) prevents the development of pulmonary hypertension (PH) in monocrotaline (MCT)-injected rats.
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Article
Skin ulcer is a predictive and prognostic factor of acute or subacute interstitial lung disease in dermatomyositis
The aim of this study was to determine whether skin ulcer can be used as a predictive and prognostic factor of acute/subacute interstitial lung disease (ILD) in Japanese patients with dermatomyositis (DM). We ...
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Article
Colforsin-induced vasodilation in chronic hypoxic pulmonary hypertension in rats
Colforsin, a water-soluble forskolin derivative, directly activates adenylate cyclase and thereby increases the 3′,5′-cyclic adenosine monophosphate (cAMP) level in vascular smooth muscle cells. In this study,...
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Article
A Novel Inhibitor of Inducible Nitric Oxide Synthase, ONO-1714, Does Not Ameliorate Hypoxia-induced Pulmonary Hypertension in Rats
A recent study showed that long-term administration of the inducible nitric oxide synthase (iNOS) inhibitor L-NIL reduced the development of pulmonary hypertension. The purpose of the present study was to iden...
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Article
Effect of nicardipine on pulmonary hypertension after repair of congenital heart defects in early postoperative period
We examined the effect of nicardipine and hyperventilatin on pulmonary arterial pressure (PAP) in four patients with pulmonary hypertension in congenital heart defect especially in the early postoperative peri...
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Article
Whole body oxygen consumption after hypothermic cardiopulmonary bypass
Whole body oxygen consumption and the substrate for energy production during the post-bypass period have not been clarified. We hypothesized that the substrate composition for energy production during post-byp...
