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Article
Effect of Recovery Heat Treatment on Microstructure and Properties of IN783 Bolts in Service
Various testing techniques established the association between precipitates and the mechanical characteristics of IN783 alloy at high temperatures. The results show that the β phase is coarser at the grain bounda...
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Article
Open AccessA new hybrid algorithm for three-stage gene selection based on whale optimization
In biomedical data mining, the gene dimension is often much larger than the sample size. To solve this problem, we need to use a feature selection algorithm to select feature gene subsets with a strong correla...
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Article
Austenite Grain Growth and Its Effect on the Mechanical Properties of Super304H Heat-Resistant Steel
In this work, Super304H steel samples of uniform, coarse austenite grains are prepared by pre-deformation and subsequent solution treatment. The grain characteristics and effects of their size on the room-temp...
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Article
Open AccessProbability distribution characteristics of summer extreme precipitation in **njiang, China during 1970–2021
Based on the daily precipitation data of 96 stations in **njiang, China, from 1970 to 2021, the trend of summer extreme precipitation indices and their regional characteristics are analyzed. The generalized ex...
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Article
Combined strategies for effective cancer immunotherapy with a novel anti-CD47 monoclonal antibody
CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic cells. CD47 serves as the ligand for a receptor on t...
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Article
Comparison and Analysis of Meteorological Variables Observed from the Glacier Area over the Tianshan Mountains in Kyrgyzstan and China
Due to the special natural environment over the glacier area in the Tianshan Mountains, the observation of meteorological data became difficult and is strictly scarce. Using the available data observed from th...
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Article
Microstructure and Mechanical Properties of P91 Steel during Heat Treatment: The Effect of the Cooling Speed during the Normalization Stage
The evolution of the microstructure and mechanical properties of P91 steel during heat treatments at different cooling speeds during the normalization stage was investigated. Results showed that normalized mar...
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Article
Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity
CD47, an immune checkpoint receptor frequently unregulated in various blood and solid tumors, interacts with ligand SIPRα on innate immune cells, and conveys a “do not eat me” signal to inhibit macrophage-medi...
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Article
Development and characterization of a novel anti-OX40 antibody for potent immune activation
With the great success of anti-CTLA-4 and anti-PD-1 therapeutics in cancer immunotherapy, tumor necrosis factor receptor superfamily members have been recognized as ideal targets to provide co-stimulatory sign...
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Article
Open AccessPotent and conditional redirected T cell killing of tumor cells using Half DVD-Ig
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on C...
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Article
Open AccessRetraction Note: Microarray analysis for differentially expressed genes of patients undergoing total knee arthroplasty with ischemia preconditioning
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Open AccessRETRACTED ARTICLE: Microarray analysis for differentially expressed genes of patients undergoing total knee arthroplasty with ischemia preconditioning
Ischemia preconditioning (IPC) has been proved as a powerful method of protecting tissues against ischemia reperfusion insults. We aimed to elucidate the mechanism of IPC in ischemia reperfused tissues.
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Protocol
Design and Generation of DVD-Ig™ Molecules for Dual-Specific Targeting
The dual variable domain immunoglobulin (DVD-IgTM) protein is a new type of dual-specific IgG. As a novel therapeutic class, the great potential of the DVD-Ig protein is to simultaneously target two mediators of ...
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Article
Open AccessNo major association between TGFBR1*6A and prostate cancer
Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused b...
