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Article
Exploiting bacteria for cancer immunotherapy
Immunotherapy has revolutionized the treatment of cancer but continues to be constrained by limited response rates, acquired resistance, toxicities and high costs, which necessitates the development of new, in...
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Article
Tumor Pre-Targeting System Using Streptavidin-Expressing Bacteria
A major obstacle to targeted cancer therapy is identifying suitable targets that are specifically and abundantly expressed by solid tumors. Certain bacterial strains selectively colonize solid tumors and can d...
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Article
Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy
Attenuated Salmonella typhimurium is a potential biotherapeutic antitumor agent because it can colonize tumors and inhibit their growth. The present study aimed to develop a doxycycline (Doxy)-inducible gene swit...
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Article
Open AccessMucosal TLR5 activation controls healthspan and longevity
Addressing age-related immunological defects through therapeutic interventions is essential for healthy aging, as the immune system plays a crucial role in controlling infections, malignancies, and in supporti...
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Article
Open AccessEnhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs
Acoustic-resolution photoacoustic microscopy (AR-PAM) enables visualization of biological tissues at depths of several millimeters with superior optical absorption contrast. However, the lateral resolution and...
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Article
Open AccessBioengineering of bacteria for cancer immunotherapy
Here, we provide a brief overview of the approaches and strategies underlying bacteria-based cancer immunotherapy (BCiT). We also describe and summarize research in the field of synthetic biology, which aims t...
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Article
Open AccessFlagellin synergistically enhances anti-tumor effect of EGFRvIII peptide in a glioblastoma-bearing mouse brain tumor model
Glioblastoma (GBM) is the most aggressive type of brain tumor with heterogeneity and strong invasive ability. Treatment of GBM has not improved significantly despite the progress of immunotherapy and classical...
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Article
Open AccessIn vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography
Invasive aspergillosis is a critical complication in immunocompromised patients with hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV‑2. Although early and accurate diagno...
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Article
Open AccessOptimized Doxycycline-Inducible Gene Expression System for Genetic Programming of Tumor-Targeting Bacteria
In the programming of tumor-targeting bacteria, various therapeutic or reporter genes are expressed by different gene-triggering strategies. Previously, we engineered pJL87 plasmid with an inducible bacterial ...
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Article
Open AccessReporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo
Bacteria-mediated cancer-targeted therapy is a novel experimental strategy for the treatment of cancers. Bacteria can be engineered to overcome a major challenge of existing therapeutics by differentiating bet...
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Article
Open AccessDevelopment of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT
In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk st...
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Article
Change of Therapeutic Response Classification According to Recombinant Human Thyrotropin-Stimulated Thyroglobulin Measured at Different Time Points in Papillary Thyroid Carcinoma
We investigated whether response classification after total thyroidectomy and radioactive iodine (RAI) therapy could be affected by serum levels of recombinant human thyrotropin (rhTSH)-stimulated thyroglobuli...
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Article
Prognostic impact of 18F-FDG PET/CT in patients with multiple myeloma presenting with renal impairment
Renal insufficiency (RI) is a frequent manifestation of multiple myeloma (MM) at time of diagnosis but there is no reliable prognostic factor for patients with MM presenting with RI. This study investigated th...
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Article
Open AccessSurvival time prediction by integrating cox proportional hazards network and distribution function network
The Cox proportional hazards model is commonly used to predict hazard ratio, which is the risk or probability of occurrence of an event of interest. However, the Cox proportional hazard model cannot directly g...
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Article
Correction to: Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria
A Correction to this paper has been published: https://doi.org/10.1007/s13139-021-00694-7
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Article
Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria
Bacterial cancer therapy (BCT) approaches have been extensively investigated because bacteria can show unique features of strong tropism for cancer, proliferation inside tumors, and antitumor immunity, while b...
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Protocol
Synthesis and Evaluation of 18F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging
We have previously reported that radiolabeled phosphonium cations accumulate in the down a transmembrane potential gradient. We present an optimized procedure for synthesis of three [18F]-labeled fluoroalkyl tr...
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Article
Clinical Impact of F-18 FDG PET-CT on Biopsy Site Selection in Patients with Suspected Bone Metastasis of Unknown Primary Site
We investigated the clinical role of F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in the identification of the primary site and the selection of the optimal biopsy si...
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Article
Open AccessBacteria-cancer interactions: bacteria-based cancer therapy
Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy, have raised the hope for cures for many cancer types. However, there are still ongoing challenges to the pursuit of novel the...
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Article
Open AccessAssociation of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects
Increasing evidence indicates that sarcopenia and obesity can be risk factors for incident dementia. We investigated the association of body composition including muscle and visceral adipose tissue (VAT) with ...
