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Open AccessPrognostic value of CT-based radiomics in grade 1–2 pancreatic neuroendocrine tumors
Surgically resected grade 1–2 (G1-2) pancreatic neuroendocrine tumors (PanNETs) exhibit diverse clinical outcomes, highlighting the need for reliable prognostic biomarkers. Our study aimed to develop and valid...
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Article
Open AccessAvailability of ChatGPT to provide medical information for patients with kidney cancer
ChatGPT is an advanced natural language processing technology that closely resembles human language. We evaluated whether ChatGPT could help patients understand kidney cancer and replace consultations with uro...
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Article
Open AccessExperience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits
Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to ea...
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Article
Open AccessDrug delivery by sonosensitive liposome and microbubble with acoustic-lens attached ultrasound: an in vivo feasibility study in a murine melanoma model
Conventional chemotherapy methods have adverse off-target effects and low therapeutic efficiencies of drug release in target tumors. In this study, we proposed a combination therapy of doxorubicin (DOX)-loaded...
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Article
Open AccessGlobal response of upper-level aviation turbulence from various sources to climate change
Atmospheric turbulence at commercial aircraft cruising altitudes is a main threat to aviation safety worldwide. As the air transport industry expands and is continuously growing, investigating global response ...
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Article
Open AccessCrystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study
BRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising therapeutic targets for treating various diseases, including ca...
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Open AccessUrinary tract infection after radiation therapy or radical prostatectomy on the prognosis of patients with prostate cancer: a population-based study
We aimed to assess the trends in urinary tract infections (UTIs) and prognosis of patients with prostate cancer after radical prostatectomy (RP) and radiation therapy (RT) as definitive treatment options.
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Open AccessFeasibility and safety of a novel 3D-printed biodegradable biliary stent in an in vivo porcine model: a preliminary study
To assess the feasibility and safety of a novel 3D-printed biodegradable biliary stent using polycaprolactone (PCL) in an in vivo porcine model. In this animal study using domestic pigs, biodegradable radiopaq...
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Article
Open AccessBMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity
Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating macrophage efferocytosis. Studies are underway to develop smal...
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Open AccessAccuracy of a surface-based fusion method when integrating digital models and the cone beam computed tomography scans with metal artifacts
The aim of this study was to evaluate the intra- and inter-observer reliability of maxillary digital dental model integration into cone-beam computed tomography (CBCT) scans to reconstruct three-dimensional (3...
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Article
Open AccessThe feasibility of deep learning-based synthetic contrast-enhanced CT from nonenhanced CT in emergency department patients with acute abdominal pain
Our objective was to investigate the feasibility of deep learning-based synthetic contrast-enhanced CT (DL-SCE-CT) from nonenhanced CT (NECT) in patients who visited the emergency department (ED) with acute ab...
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Open AccessPreclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens
Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to i...
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Article
Open AccessHybrid ileal pouch with concomitant anti-refluxing and refluxing ureteroileal anastomosis
We report our preliminary experience of using a hybrid ileal pouch, assessing oncologic outcomes, complications, voiding, and renal function.
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Article
Open AccessSynthesis of silver nanoparticles embedded with single-walled carbon nanotubes for printable elastic electrodes and sensors with high stability
Soft electronic devices that are bendable and stretchable require stretchable electric or electronic components. Nanostructured conducting materials or soft conducting polymers are one of the most promising fi...
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Article
Open AccessNeuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation
The root of Angelica gigas Nakai (Apiaceae) has been traditionally used as an important herbal medicine to treat blood-deficiency-related disorders in Eastern Asian countries, and recently, it has been recognized...
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Article
Open AccessDeep learning-based decision support system for the diagnosis of neoplastic gallbladder polyps on ultrasonography: Preliminary results
Ultrasonography (US) has been considered image of choice for gallbladder (GB) polyp, however, it had limitations in differentiating between nonneoplastic polyps and neoplastic polyps. We developed and investig...
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Article
Open AccessDevelopment of a 3D Printer for Concrete Structures: Laboratory Testing of Cementitious Materials
This study deals with (a) the development of a prototype 3D printer for concrete structures having a bed size of 1 × 1 × 1 m for a laboratory testing and (b) laboratory testing of cementitious materials with d...
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Article
Open AccessPlasma virtual roughness elements for cross-flow instability control
Recent experiments and numerical simulations demonstrated that discrete roughness elements can be used to control cross-flow instability over a swept wing. Here, the application of this passive technique requi...
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Article
Open AccessAptamer-modified Magnetic Nanosensitizer for in vivo MR imaging of HER2-expressing Cancer
The aim of this study was the development of a human epidermal growth factor receptor 2 (HER2)-targetable contrast agent for magnetic resonance imaging (MRI) with a high magnetic sensitivity. An anti-HER2 apta...
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Open AccessLoss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
AMP-activated protein kinase (AMPK) plays a key role in controlling energy metabolism in response to physiological and nutritional status. Although AMPK activation has been proposed as a promising molecular ta...