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Article
Open AccessIntracellular lipophilic network transformation induced by protease-specific endocytosis of fluorescent Au nanoclusters
The understanding of the endocytosis process of internalized nanomedicines through membrane biomarker is essential for the development of molecular-specific nanomedicines. In various recent reports, the metall...
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Article
Open AccessER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1
C1q/TNF-related protein 1 (CTRP1) is a CTRP family member that has collagenous and globular C1q-like domains. The secreted form of CTRP1 is known to be associated with cardiovascular and metabolic diseases, bu...
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Article
Open AccessRadiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
We investigated the effectiveness of soluble Receptor for Advanced Glycation Endproducts (sRAGE) in attenuating angiotensin II (AngII)-induced left ventricular hypertrophy (LVH) using in vivo 9.4T cine-magnetic r...
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Article
Open AccessBeyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer
Epidermal growth factor receptor (EGFR) overexpression is common in head and neck squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been an area of keen interest in head and neck...
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Article
Open AccessAptamer-modified Magnetic Nanosensitizer for in vivo MR imaging of HER2-expressing Cancer
The aim of this study was the development of a human epidermal growth factor receptor 2 (HER2)-targetable contrast agent for magnetic resonance imaging (MRI) with a high magnetic sensitivity. An anti-HER2 apta...
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Article
Open AccessImplantable Photothermal Agents based on Gold Nanorods-Encapsulated Microcube
Gold nanorods (GNRs) are of great interest in cancer therapy given their ability to ablate tumor cells using deep tissue-penetrating near-infrared light. GNRs coated with tumor-specific moieties have the poten...
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Article
Detection and Correction of Laterality Errors in Radiology Reports
The objectives of the study are to introduce the development of supervising software for double-checking of laterality error in radiology reports and to evaluate the usefulness of detection and correction soft...
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Article
Metabolism in embryonic and cancer stemness
Cells constantly adjust their metabolic state in response to extracellular signals and nutrient availability to meet their demand for energy and building blocks. Recently, there has been significant research i...
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Article
Open AccessAptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature
Nucleic acid-based aptamers have been developed for the specific delivery of diagnostic nanoprobes. Here, we introduce a new class of smart imaging nanoprobe, which is based on hybridization of a magnetic nano...
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Article
Redox-sensitive colorimetric polyaniline nanoprobes synthesized by a solvent-shift process
We have synthesized water-stable polyaniline nanoparticles coated with triarmed polyethylene glycol chains using a solvent-shift method and confirmed their colloidal size and aqueous solubility. Furthermore, w...
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Article
Open AccessDouble-ligand modulation for engineering magnetic nanoclusters
Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy ...
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Article
Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy
Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In ...
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Article
Open AccessNanomechanical characterization of chemical interaction between gold nanoparticles and chemical functional groups
We report on how to quantify the binding affinity between a nanoparticle and chemical functional group using various experimental methods such as cantilever assay, PeakForce quantitative nanomechanical propert...
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Article
Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells
For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed u...
