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Article
Constructing a disulfidptosis-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing and weighted co-expression network analysis
Hepatocellular carcinoma (HCC) ranks as the second leading cause of cancer-related deaths globally. Disulfidptosis is a newly identified form of regulated cell death that is induced by glucose starvation. Howe...
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Article
Open AccessHighly efficient in crystallo energy transduction of light to work
Various mechanical effects have been reported with molecular materials, yet organic crystals capable of multiple dynamic effects are rare, and at present, their performance is worse than some of the common act...
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Article
Open AccessCCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer
Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential tumorigenic roles in a variety of malignancies. However, there is no system...
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Article
Open AccessThe distribution characteristics of strabismus surgery types in a tertiary hospital in the Central Plains region during the COVID-19 epidemic
This study aimed to analyze the distribution of different types of strabismus surgery in a tertiary hospital in Central China during the three-year period of the COVID-19 pandemic.
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Article
Meta-analysis on clinical outcomes of suprapapillary versus transpapillary stent insertion in malignant biliary obstruction
Endoscopic biliary stenting is an essential treatment for malignant biliary obstruction (MBO). However, the optimal location for the placement of metal stents (MS) or plastic stents (PS) during the management ...
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Article
In vitro adventitious regeneration and plantlet transplantation of Atractylodes chinensis (DC.) Koidz., a valuable medicinal plant
Triploid Atractylodes chinensis (DC.) Koidz. is a valuable genetic resource for medicinal plant breeding, and there is a demand to develop an efficient in vitro regeneration protocol to resolve triploid sterility...
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Article
Open AccessBoosting inhibition performance of natural polyphenols for the prevention of calcium oxalate kidney stones through synergistic cooperativity
Binary drug combination usually targets different pathways to achieve cooperative therapy, but the exploitation of synergistic cooperativity between crystal growth modifiers that bind to the same site for prev...
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Article
Constructing a molecular crystal actuator from pamoic acid with multilevel enhanced photoluminescence by cocrystallization
高效的光致发光性能促进了晶体材料的发展. 在本文中, 我们通 过引入溶剂分子报道了两例新的双羟萘酸多组分晶体. 通过聚集诱导 发射和共结晶诱导发射增**, 双羟萘酸多组分晶体的绝对量子产率逐 步增**, 最高达52.99%, 据我们所知, 这是目前报道的最大值. 此外, 随 着溶剂分子逃逸, 该系统表现出温度依赖的荧光响应和热诱导的机械 运动, 包括跳跃、摆动、翻转、移动和旋转. 本工作提出的引入共结晶 组分实现材料发...
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Article
Open AccessPDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma
The prognosis of renal cell carcinoma (RCC) remains poor due to metastases and resistance to chemotherapy. Salinomycin (Sal) exhibits the potential of antitumor, while the underlying mechanism is not completel...
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Article
Open AccessHDAC inhibitor ITF2357 reduces resistance of mutant-KRAS non-small cell lung cancer to pemetrexed through a HDAC2/miR-130a-3p-dependent mechanism
Histone deacetylases (HDAC) contribute to oncogenic program, pointing to their inhibitors as a potential strategy against cancers. We, thus, studied the mechanism of HDAC inhibitor ITF2357 in resistance of mut...
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Article
Plasma-enabled synthesis of ordered PtFe alloy nanoparticles encapsulated with ultrathin N-doped carbon shells for efficient methanol electrooxidation
Methanol oxidation reaction (MOR), the key reaction for clean energy generation in fuel cells, is kinetically sluggish and short-lasting because of insufficient catalytic activity and stability of the common P...
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Chapter and Conference Paper
Physiological and Psychological Effects of Light Illumination on Hygiene Regions of Space Stations in Short-Term Simulations of Gravity and Noise
Astronauts are forced to deal with stress from microgravity, claustrophobic environments and loud noise during missions on the space station, which can have a variety of negative psychological and physiologica...
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Chapter and Conference Paper
Recovery Effect of Different Virtual Natural Environments on Stress in Short-Term Isolation Tasks
On deep space missions, astronauts must endure isolated, confined and extreme (ICE) environments with no access to normal earthly comforts, which can cause severe physical and emotional stress
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Article
Correction to: The assessment of the ASGE‑grading system of ERCP: a large‑sample retrospective study
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Article
The assessment of the ASGE-grading system of ERCP: a large-sample retrospective study
The American Society for Gastrointestinal Endoscopy (ASGE) has developed a complexity-grading system for endoscopic retrograde cholangiopancreatography (ERCP) to predict technical success and adverse events. T...
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Article
Open AccessHelicobacter pylori infection activates Wnt/β-catenin pathway to promote the occurrence of gastritis by upregulating ASCL1 and AQP5
Helicobacter pylori (H. pylori) infection is a well-recognized contributing factor to gastritis, but the underlying mechanisms remain to be established. It is interesting to note that AQP5 was predicted to be hig...
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Article
Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients in industrial crystallization
Solubility has been widely regarded as a fundamental property of small molecule drugs and drug candidates, as it has a profound impact on the crystallization process. Solubility prediction, as an alternative t...
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Chapter
Process Control and Intensification of Solution Crystallization
Solution crystallization attracts more and more attention in the pharmaceutical industries because of the functions of separation and the tuning ability of solid-state properties at the molecular level. Genera...
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Article
Open AccessThe key regulator LcERF056 enhances salt tolerance by modulating reactive oxygen species-related genes in Lotus corniculatus
The APETALA2/ethylene response factor (AP2/ERF) family are important regulatory factors involved in plants’ response to environmental stimuli. However, their roles in salt tolerance in Lotus corniculatus remain u...
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Article
Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery
Drugs are referred to as drug nanocrystals when they exist as nanoscale crystal structures. This kind of nanocarrier has been widely utilized to increase the solubility and absorption for poorly aqueous solubl...
